Human α2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene

Funmei Yang, Zi Lian Chen, Judith M. Bergeron, Rod L. Cupples, William E. Friedrichs

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Human α2-HS-glycoprotein (AHSG) is a plasma protein synthesized in liver and selectively concentrated in bone matrix. It has been reported to be involved in bone formation and resorption as well as immune responses. Recently, AHSG was found to be the species equivalent protein of fetuin, the major fetal serum protein in cattle and sheep. The function and regulation of AHSG/fetuin in different species are not understood. We have isolated a liver cDNA clone that encodes the human AHSG/bovine fetuin homologue in the mouse. The AHSG/fetuin gene may have a role in differentiation since it is expressed in mouse limb buds and brain only at certain stages during development. Mouse liver AHSG/fetuin mRNA was present at low level at 12 days gestation but its level increased during the late part of gestation and peaked between 1 to 3 months after birth. The regulation of mouse AHSG/fetuin synthesis during development was found to be significantly different from that of sheep and bovine fetuin. Compared to fetuin, which is reduced in adult to 1 to 2% of the fetal level, mouse AHSG synthesis subsides only 50% 4 months after birth.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalBBA - Gene Structure and Expression
Volume1130
Issue number2
DOIs
StatePublished - Mar 24 1992

Keywords

  • Development
  • Fetuin
  • Gene regulation
  • mRNA
  • α-HS-glycoprotein

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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