@article{bae5ee1293034cbfadeccb0467d8fd2c,
title = "Hox Repertoires for Motor Neuron Diversity and Connectivity Gated by a Single Accessory Factor, FoxP1",
abstract = "The precision with which motor neurons innervate target muscles depends on a regulatory network of Hox transcription factors that translates neuronal identity into patterns of connectivity. We show that a single transcription factor, FoxP1, coordinates motor neuron subtype identity and connectivity through its activity as a Hox accessory factor. FoxP1 is expressed in Hox-sensitive motor columns and acts as a dose-dependent determinant of columnar fate. Inactivation of Foxp1 abolishes the output of the motor neuron Hox network, reverting the spinal motor system to an ancestral state. The loss of FoxP1 also changes the pattern of motor neuron connectivity, and in the limb motor axons appear to select their trajectories and muscle targets at random. Our findings show that FoxP1 is a crucial determinant of motor neuron diversification and connectivity, and clarify how this Hox regulatory network controls the formation of a topographic neural map.",
keywords = "DEVBIO, EVO_ECOL, MOLNEURO",
author = "Dasen, {Jeremy S.} and {De Camilli}, Alessandro and Bin Wang and Tucker, {Philip W.} and Jessell, {Thomas M.}",
note = "Funding Information: We thank J. Kirkland, M. Mendelsohn, S. Maika and the NYU transgenic facility for mouse husbandry, S. Morton for antibody generation, N. Permaul for assistance, K. MacArthur and I. Schieren for help with the manuscript. N. De Marco and G. Surmeli identified muscle nerves, R. Mann advised on Hox biology, J. Fetcho and M. Cohn on motor system and limb evolution. E. Laufer showed that pSmad is a PGC marker, C. Henderson that Er81 marks HMC neurons. J. Brown kindly let us cite her unpublished data. S. Arber, R. Axel, G. Fishell, C. Henderson, R. Mann and S. Poliak provided comments on the manuscript. J.D. is supported by a Burroughs Welcome Fund CABS and a Whitehead Fellowship, P.W.T. by a National Institutes of Health CA031534 and a Marie Betzner Morrow Centennial Endowment, and T.M.J. by NINDS 5R01033245, The Wellcome Trust, Project ALS and the NYSCIRP. T.M.J. is a Howard Hughes Medical Institute investigator. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2008",
month = jul,
day = "25",
doi = "10.1016/j.cell.2008.06.019",
language = "English (US)",
volume = "134",
pages = "304--316",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}