How Ebola and Marburg viruses battle the immune system

Mansour Mohamadzadeh; Lieping Chen; Alan L. Schmaljohn

doi:10.1038/nri2098

How Ebola and Marburg viruses battle the immune system

Mansour Mohamadzadeh, Lieping Chen, Alan L. Schmaljohn

Research output: Contribution to journal › Review article › peer-review

111 Scopus citations

Abstract

The filoviruses Ebola and Marburg have emerged in the past decade from relative obscurity to serve now as archetypes for some of the more intriguing and daunting challenges posed by such agents. Public imagination is captured by deadly outbreaks of these viruses and reinforced by the specter of bioterrorism. As research on these agents has accelerated, it has been found increasingly that filoviruses use a combination of familiar and apparently new ways to baffle and battle the immune system. Filoviruses have provided thereby a new lens through which to examine the immune system itself.

Original language	English (US)
Pages (from-to)	556-567
Number of pages	12
Journal	Nature Reviews Immunology
Volume	7
Issue number	7
DOIs	https://doi.org/10.1038/nri2098
State	Published - Jul 2007
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1038/nri2098

Cite this

@article{222c0e4f16284ed5baab8fa20bc8234a,

title = "How Ebola and Marburg viruses battle the immune system",

abstract = "The filoviruses Ebola and Marburg have emerged in the past decade from relative obscurity to serve now as archetypes for some of the more intriguing and daunting challenges posed by such agents. Public imagination is captured by deadly outbreaks of these viruses and reinforced by the specter of bioterrorism. As research on these agents has accelerated, it has been found increasingly that filoviruses use a combination of familiar and apparently new ways to baffle and battle the immune system. Filoviruses have provided thereby a new lens through which to examine the immune system itself.",

author = "Mansour Mohamadzadeh and Lieping Chen and Schmaljohn, {Alan L.}",

note = "Funding Information: The views, opinions and/or findings contained in this report are those of the authors and should not be construed as an official Department of the Army or Johns Hopkins University position, policy, or decision unless designated by other documentation. This work was supported in part by the Defense Threat Reduction Agency.",

year = "2007",

month = jul,

doi = "10.1038/nri2098",

language = "English (US)",

volume = "7",

pages = "556--567",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

publisher = "Nature Research",

number = "7",

}

TY - JOUR

T1 - How Ebola and Marburg viruses battle the immune system

AU - Mohamadzadeh, Mansour

AU - Chen, Lieping

AU - Schmaljohn, Alan L.

N1 - Funding Information: The views, opinions and/or findings contained in this report are those of the authors and should not be construed as an official Department of the Army or Johns Hopkins University position, policy, or decision unless designated by other documentation. This work was supported in part by the Defense Threat Reduction Agency.

PY - 2007/7

Y1 - 2007/7

N2 - The filoviruses Ebola and Marburg have emerged in the past decade from relative obscurity to serve now as archetypes for some of the more intriguing and daunting challenges posed by such agents. Public imagination is captured by deadly outbreaks of these viruses and reinforced by the specter of bioterrorism. As research on these agents has accelerated, it has been found increasingly that filoviruses use a combination of familiar and apparently new ways to baffle and battle the immune system. Filoviruses have provided thereby a new lens through which to examine the immune system itself.

AB - The filoviruses Ebola and Marburg have emerged in the past decade from relative obscurity to serve now as archetypes for some of the more intriguing and daunting challenges posed by such agents. Public imagination is captured by deadly outbreaks of these viruses and reinforced by the specter of bioterrorism. As research on these agents has accelerated, it has been found increasingly that filoviruses use a combination of familiar and apparently new ways to baffle and battle the immune system. Filoviruses have provided thereby a new lens through which to examine the immune system itself.

UR - http://www.scopus.com/inward/record.url?scp=34250863265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250863265&partnerID=8YFLogxK

U2 - 10.1038/nri2098

DO - 10.1038/nri2098

M3 - Review article

C2 - 17589545

AN - SCOPUS:34250863265

SN - 1474-1733

VL - 7

SP - 556

EP - 567

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 7

ER -

How Ebola and Marburg viruses battle the immune system

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this