Housing density does not influence the longevity effect of calorie restriction

Yuji Ikeno, Gene B. Hubbard, Shuko Lee, Arlan Richardson, Randy Strong, Vivian Diaz, James F. Nelson

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


This study examined the effect of housing density on the longevity-extending and disease-delaying actions of calorie restriction (CR). Singly or multiply housed (four per cage) mice were either fed ad libitum (AL) or were on CR beginning at 2 months. All CR mice were fed 40% less food than were multiply housed AL mice. CR increased median longevity by 19%, and housing density had no effect on this increase. CR also reduced neoplastic lesions in both housing groups, but lymphoma, the most common neoplasm, was reduced more in singly than in multiply housed mice. Singly housed AL mice ate 40% more food than did multiply housed AL mice, but weighed the same and lived as long as multiply housed AL mice. These results indicate that CR can extend life span as effectively in multiply as in singly housed mice, even though housing density can differentially affect the cancer-reducing effect of CR.

Original languageEnglish (US)
Pages (from-to)1510-1517
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number12
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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