House dust mite exposure attenuates influenza A infection in a mouse model of pulmonary allergic inflammation

Qiyao Hu, Ryan P. Gilley, Peter H Dube

Research output: Contribution to journalArticle

Abstract

Environmental allergens elicit complex immune responses in the lungs that can promote the development of asthma or exacerbate preexisting asthma in susceptible individuals. House dust mites are one of the most common indoor allergens and are a significant driver of allergic disease. Respiratory infections are known factors in acute exacerbations of asthma but the impact of allergen on the pathogen is not well understood. We investigated the pathogenesis of influenza A infection following exposure to house dust mites. Mice exposed to house dust mites lose less weight following infection and had more transcription of interferon-lambda than controls. These data correlated with less transcription of the influenza polymerase acidic gene suggesting diminished viral replication in house dust mite exposed mice. Altogether, these data suggest that exposure to environmental allergens can influence the pathogenesis of influenza infection.

Original languageEnglish (US)
Pages (from-to)242-249
Number of pages8
JournalMicrobial Pathogenesis
Volume129
DOIs
StatePublished - Apr 1 2019

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Keywords

  • Allergy
  • Asthma
  • House dust mite
  • Inflammation
  • Influenza

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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