HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Huacheng Luo; Ganqian Zhu; Jianfeng Xu; Qian Lai; Bowen Yan; Ying Guo; Tsz Kan Fung; Bernd B. Zeisig; Ya Cui; Jie Zha; Christopher Cogle; Fei Wang; Bing Xu; Feng Chun Yang; Wei Li; Chi Wai Eric So; Yi Qiu; Mingjiang Xu; Suming Huang

doi:10.1016/j.ccell.2019.10.011

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Huacheng Luo, Ganqian Zhu, Jianfeng Xu, Qian Lai, Bowen Yan, Ying Guo, Tsz Kan Fung, Bernd B. Zeisig, Ya Cui, Jie Zha, Christopher Cogle, Fei Wang, Bing Xu, Feng Chun Yang, Wei Li, Chi Wai Eric So, Yi Qiu, Mingjiang Xu, Suming Huang

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.

Original language	English (US)
Pages (from-to)	645-659.e8
Journal	Cancer Cell
Volume	36
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2019.10.011
State	Published - Dec 9 2019

Keywords

CTCF boundary
HOTTIP lncRNA
HOTTIP transgenic mice
HOX and hematopoietic gene regulation
HSC self-renewal
WNT signaling targets
chromatin domain
enhancer/promoter accessibility
leukemia

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2019.10.011

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Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F. C., Li, W., So, C. W. E., Qiu, Y., Xu, M., & Huang, S. (2019). HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice. Cancer Cell, 36(6), 645-659.e8. https://doi.org/10.1016/j.ccell.2019.10.011

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title = "HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice",

abstract = "Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.",

keywords = "CTCF boundary, HOTTIP lncRNA, HOTTIP transgenic mice, HOX and hematopoietic gene regulation, HSC self-renewal, WNT signaling targets, chromatin domain, enhancer/promoter accessibility, leukemia",

author = "Huacheng Luo and Ganqian Zhu and Jianfeng Xu and Qian Lai and Bowen Yan and Ying Guo and Fung, {Tsz Kan} and Zeisig, {Bernd B.} and Ya Cui and Jie Zha and Christopher Cogle and Fei Wang and Bing Xu and Yang, {Feng Chun} and Wei Li and So, {Chi Wai Eric} and Yi Qiu and Mingjiang Xu and Suming Huang",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

day = "9",

doi = "10.1016/j.ccell.2019.10.011",

language = "English (US)",

volume = "36",

pages = "645--659.e8",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

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TY - JOUR

T1 - HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

AU - Luo, Huacheng

AU - Zhu, Ganqian

AU - Xu, Jianfeng

AU - Lai, Qian

AU - Yan, Bowen

AU - Guo, Ying

AU - Fung, Tsz Kan

AU - Zeisig, Bernd B.

AU - Cui, Ya

AU - Zha, Jie

AU - Cogle, Christopher

AU - Wang, Fei

AU - Xu, Bing

AU - Yang, Feng Chun

AU - Li, Wei

AU - So, Chi Wai Eric

AU - Qiu, Yi

AU - Xu, Mingjiang

AU - Huang, Suming

PY - 2019/12/9

Y1 - 2019/12/9

N2 - Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.

AB - Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.

KW - CTCF boundary

KW - HOTTIP lncRNA

KW - HOTTIP transgenic mice

KW - HOX and hematopoietic gene regulation

KW - HSC self-renewal

KW - WNT signaling targets

KW - chromatin domain

KW - enhancer/promoter accessibility

KW - leukemia

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DO - 10.1016/j.ccell.2019.10.011

M3 - Article

C2 - 31786140

AN - SCOPUS:85075878690

SN - 1535-6108

VL - 36

SP - 645-659.e8

JO - Cancer Cell

JF - Cancer Cell

IS - 6

ER -

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Abstract

Keywords

ASJC Scopus subject areas

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