Host-parasite interactions in the pathogenesis of experimental renal candidiasis

J. L. Barnes, R. W. Osgood, J. C. Lee, R. D. King, J. H. Stein

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

To study the pathogenesis of renal candidiasis, viable Candida albicans blastospores were injected directly into the left renal artery of New Zealand white rabbits. The progression of the disease was followed by light and electron microscopy over a 6-day period. Within 5 minutes after injection of the yeasts, the organisms localized within glomerular and peritubular capillaries of the cortex. Localization of yeasts within the capillaries occurred through adherence, demonstrated by the presence of surface fibrils originating from the yeast cells. Two to 10 hours later, inflammatory nodules comprised of polymorphonuclear leukocytes formed within capillary lumina. Many of the entrapped yeasts remained viable and extended through adjacent endothelium and epithelium by the formation of germ tubes which penetrated between or directly through intact host cells. After 24 hours, numerous hyphal forms were observed within tubules of the cortex, and some necrotic host cells were noted at sites of penetration. Abscesses replaced renal parenchyma in focal areas during subsequent time intervals. These studies indicate that attachment of Candida albicans to endothelium within capillaries of the cortex is a key event in the disease process. Also, growth of germ tubes into renal tubules provides a temporal advantage for amplification of Candida organisms.

Original languageEnglish (US)
Pages (from-to)460-467
Number of pages8
JournalLaboratory Investigation
Volume49
Issue number4
StatePublished - 1983

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Host-Parasite Interactions
Candidiasis
Yeasts
Kidney
Candida albicans
Vascular Endothelium
Renal Artery
Candida
Abscess
Endothelium
Disease Progression
Electron Microscopy
Neutrophils
Epithelium
Rabbits
Light
Injections
Growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Barnes, J. L., Osgood, R. W., Lee, J. C., King, R. D., & Stein, J. H. (1983). Host-parasite interactions in the pathogenesis of experimental renal candidiasis. Laboratory Investigation, 49(4), 460-467.

Host-parasite interactions in the pathogenesis of experimental renal candidiasis. / Barnes, J. L.; Osgood, R. W.; Lee, J. C.; King, R. D.; Stein, J. H.

In: Laboratory Investigation, Vol. 49, No. 4, 1983, p. 460-467.

Research output: Contribution to journalArticle

Barnes, JL, Osgood, RW, Lee, JC, King, RD & Stein, JH 1983, 'Host-parasite interactions in the pathogenesis of experimental renal candidiasis', Laboratory Investigation, vol. 49, no. 4, pp. 460-467.
Barnes JL, Osgood RW, Lee JC, King RD, Stein JH. Host-parasite interactions in the pathogenesis of experimental renal candidiasis. Laboratory Investigation. 1983;49(4):460-467.
Barnes, J. L. ; Osgood, R. W. ; Lee, J. C. ; King, R. D. ; Stein, J. H. / Host-parasite interactions in the pathogenesis of experimental renal candidiasis. In: Laboratory Investigation. 1983 ; Vol. 49, No. 4. pp. 460-467.
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