TY - JOUR
T1 - Host genetics and population structure effects on parasitic disease
AU - Williams-Blangero, Sarah
AU - Criscione, Charles D.
AU - VandeBerg, John L.
AU - Correa-Oliveira, Rodrigo
AU - Williams, Kimberly D.
AU - Subedi, Janardan
AU - Kent, Jack W.
AU - Williams, Jeff
AU - Kumar, Satish
AU - Blangero, John
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Host genetic factors exert significant influences on differential susceptibility to many infectious diseases. In addition, population structure of both host and parasite may influence disease distribution patterns. In this study, we assess the effects of population structure on infectious disease in two populations in which host genetic factors influencing susceptibility to parasitic disease have been extensively studied. The first population is the Jirel population of eastern Nepal that has been the subject of research on the determinants of differential susceptibility to soil-transmitted helminth infections. The second group is a Brazilian population residing in an area endemic for Trypanosoma cruzi infection that has been assessed for genetic influences on differential disease progression in Chagas disease. For measures of Ascaris worm burden, within-population host genetic effects are generally more important than host population structure factors in determining patterns of infectious disease. No significant influences of population structure on measures associated with progression of cardiac disease in individuals who were seropositive for T. cruzi infection were found.
AB - Host genetic factors exert significant influences on differential susceptibility to many infectious diseases. In addition, population structure of both host and parasite may influence disease distribution patterns. In this study, we assess the effects of population structure on infectious disease in two populations in which host genetic factors influencing susceptibility to parasitic disease have been extensively studied. The first population is the Jirel population of eastern Nepal that has been the subject of research on the determinants of differential susceptibility to soil-transmitted helminth infections. The second group is a Brazilian population residing in an area endemic for Trypanosoma cruzi infection that has been assessed for genetic influences on differential disease progression in Chagas disease. For measures of Ascaris worm burden, within-population host genetic effects are generally more important than host population structure factors in determining patterns of infectious disease. No significant influences of population structure on measures associated with progression of cardiac disease in individuals who were seropositive for T. cruzi infection were found.
KW - Chagas disease
KW - Genetics of infectious disease susceptibility
KW - Intestinal worms
KW - Population structure
UR - http://www.scopus.com/inward/record.url?scp=84863011408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863011408&partnerID=8YFLogxK
U2 - 10.1098/rstb.2011.0296
DO - 10.1098/rstb.2011.0296
M3 - Article
C2 - 22312056
AN - SCOPUS:84863011408
VL - 367
SP - 887
EP - 894
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0800-4622
IS - 1590
ER -