Host defense mechanisms in the peritoneal cavity of continuous ambulatory peritoneal dialysis patients. First of two parts

S. Lewis, C. Holmes

    Research output: Contribution to journalReview articlepeer-review

    54 Scopus citations

    Abstract

    This article provides a review of studies on peritoneal white blood cells (WBC) in CAPD patients. To some extent these studies support the concept that the peritoneal cavity of these patients contains adequate-functioning WBC that can provide effective antimicrobial defenses when they are studied in dialysate-free media. Commercially available dialysis solutions significantly impair WBC function. In some patients with high incidences of peritonitis, there appears to be reduced bactericidal capacity of their peritoneal macrophages. CAPD seems to contribute to a state of both macrophage and lymphocyte activation in the peritoneal cavity. The clinical consequences of this chronic activation are not known.

    Original languageEnglish (US)
    Pages (from-to)14-21
    Number of pages8
    JournalPeritoneal Dialysis International
    Volume11
    Issue number1
    DOIs
    StatePublished - 1991

    Keywords

    • cytokines
    • host defense
    • immune system
    • macrophages
    • peritoneal white cells

    ASJC Scopus subject areas

    • Nephrology

    Fingerprint

    Dive into the research topics of 'Host defense mechanisms in the peritoneal cavity of continuous ambulatory peritoneal dialysis patients. First of two parts'. Together they form a unique fingerprint.

    Cite this