Abstract
Because of its neuroendocrine effects, amphetamine infusion has been used as a probe to investigate neurobiological correlates of depressive illness. In two separate studies, a total of 72 adolescents with major depressive disorder and 66 normal adolescents were given dextroamphetamine, 0.15 mg/kg, intravenously. Their cortisol, growth hormone, and prolactin responses were measured. These endocrine responses did not reliably distinguish adolescents with major depressive disorder from those without it, nor did they reliably delinate any specific depressive subgroup. These findings are compared with those from similar studies of adult depression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 415-422 |
| Number of pages | 8 |
| Journal | Journal of the American Academy of Child and Adolescent Psychiatry |
| Volume | 30 |
| Issue number | 3 |
| State | Published - 1991 |
| Externally published | Yes |
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Keywords
- Adolescence
- Amphetamine
- Depression
- Neuroendocrine
ASJC Scopus subject areas
- Psychiatry and Mental health
- Developmental and Educational Psychology
Cite this
Hormonal responses to dextroamphetamine in depressed and normal adolescents. / Waterman, G. S.; Ryan, N. D.; Puig-Antich, J.; Meyer, V.; Ambrosini, P. J.; Rabinovich, H.; Stull, S.; Novacenko, H.; Williamson, D. E.; Nelson, B.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 30, No. 3, 1991, p. 415-422.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hormonal responses to dextroamphetamine in depressed and normal adolescents
AU - Waterman, G. S.
AU - Ryan, N. D.
AU - Puig-Antich, J.
AU - Meyer, V.
AU - Ambrosini, P. J.
AU - Rabinovich, H.
AU - Stull, S.
AU - Novacenko, H.
AU - Williamson, D. E.
AU - Nelson, B.
PY - 1991
Y1 - 1991
N2 - Because of its neuroendocrine effects, amphetamine infusion has been used as a probe to investigate neurobiological correlates of depressive illness. In two separate studies, a total of 72 adolescents with major depressive disorder and 66 normal adolescents were given dextroamphetamine, 0.15 mg/kg, intravenously. Their cortisol, growth hormone, and prolactin responses were measured. These endocrine responses did not reliably distinguish adolescents with major depressive disorder from those without it, nor did they reliably delinate any specific depressive subgroup. These findings are compared with those from similar studies of adult depression.
AB - Because of its neuroendocrine effects, amphetamine infusion has been used as a probe to investigate neurobiological correlates of depressive illness. In two separate studies, a total of 72 adolescents with major depressive disorder and 66 normal adolescents were given dextroamphetamine, 0.15 mg/kg, intravenously. Their cortisol, growth hormone, and prolactin responses were measured. These endocrine responses did not reliably distinguish adolescents with major depressive disorder from those without it, nor did they reliably delinate any specific depressive subgroup. These findings are compared with those from similar studies of adult depression.
KW - Adolescence
KW - Amphetamine
KW - Depression
KW - Neuroendocrine
UR - http://www.scopus.com/inward/record.url?scp=47649109547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47649109547&partnerID=8YFLogxK
M3 - Article
C2 - 2055877
AN - SCOPUS:47649109547
VL - 30
SP - 415
EP - 422
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
SN - 0890-8567
IS - 3
ER -