Hormonal responses to dextroamphetamine in depressed and normal adolescents

G. S. Waterman, N. D. Ryan, J. Puig-Antich, V. Meyer, P. J. Ambrosini, H. Rabinovich, S. Stull, H. Novacenko, D. E. Williamson, B. Nelson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Because of its neuroendocrine effects, amphetamine infusion has been used as a probe to investigate neurobiological correlates of depressive illness. In two separate studies, a total of 72 adolescents with major depressive disorder and 66 normal adolescents were given dextroamphetamine, 0.15 mg/kg, intravenously. Their cortisol, growth hormone, and prolactin responses were measured. These endocrine responses did not reliably distinguish adolescents with major depressive disorder from those without it, nor did they reliably delinate any specific depressive subgroup. These findings are compared with those from similar studies of adult depression.

Original languageEnglish (US)
Pages (from-to)415-422
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume30
Issue number3
StatePublished - 1991
Externally publishedYes

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Dextroamphetamine
Major Depressive Disorder
Amphetamine
Prolactin
Growth Hormone
Hydrocortisone
Depression

Keywords

  • Adolescence
  • Amphetamine
  • Depression
  • Neuroendocrine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Waterman, G. S., Ryan, N. D., Puig-Antich, J., Meyer, V., Ambrosini, P. J., Rabinovich, H., ... Nelson, B. (1991). Hormonal responses to dextroamphetamine in depressed and normal adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 30(3), 415-422.

Hormonal responses to dextroamphetamine in depressed and normal adolescents. / Waterman, G. S.; Ryan, N. D.; Puig-Antich, J.; Meyer, V.; Ambrosini, P. J.; Rabinovich, H.; Stull, S.; Novacenko, H.; Williamson, D. E.; Nelson, B.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 30, No. 3, 1991, p. 415-422.

Research output: Contribution to journalArticle

Waterman, GS, Ryan, ND, Puig-Antich, J, Meyer, V, Ambrosini, PJ, Rabinovich, H, Stull, S, Novacenko, H, Williamson, DE & Nelson, B 1991, 'Hormonal responses to dextroamphetamine in depressed and normal adolescents', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 30, no. 3, pp. 415-422.
Waterman GS, Ryan ND, Puig-Antich J, Meyer V, Ambrosini PJ, Rabinovich H et al. Hormonal responses to dextroamphetamine in depressed and normal adolescents. Journal of the American Academy of Child and Adolescent Psychiatry. 1991;30(3):415-422.
Waterman, G. S. ; Ryan, N. D. ; Puig-Antich, J. ; Meyer, V. ; Ambrosini, P. J. ; Rabinovich, H. ; Stull, S. ; Novacenko, H. ; Williamson, D. E. ; Nelson, B. / Hormonal responses to dextroamphetamine in depressed and normal adolescents. In: Journal of the American Academy of Child and Adolescent Psychiatry. 1991 ; Vol. 30, No. 3. pp. 415-422.
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