Because of its neuroendocrine effects, amphetamine infusion has been used as a probe to investigate neurobiological correlates of depressive illness. In two separate studies, a total of 72 adolescents with major depressive disorder and 66 normal adolescents were given dextroamphetamine, 0.15 mg/kg, intravenously. Their cortisol, growth hormone, and prolactin responses were measured. These endocrine responses did not reliably distinguish adolescents with major depressive disorder from those without it, nor did they reliably delineate any specific depressive subgroup. These findings are compared with those from similar studies of adult depression.
|Original language||English (US)|
|Number of pages||8|
|Journal||Journal of the American Academy of Child and Adolescent Psychiatry|
|State||Published - Jan 1 1991|
ASJC Scopus subject areas
- Developmental and Educational Psychology
- Psychiatry and Mental health