Hormonal Responses to Dextroamphetamine in Depressed and Normal Adolescents

G. SCOTT WATERMAN, NEAL D. RYAN, JOAQUIM PUIG-ANTICH, VIVECA MEYER, PAUL J. AMBROSINI, HARRIS RABINOVICH, STACY STULL, HANA NOVACENKO, DOUGLAS E. WILLIAMSON, BEVERLY NELSON

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Because of its neuroendocrine effects, amphetamine infusion has been used as a probe to investigate neurobiological correlates of depressive illness. In two separate studies, a total of 72 adolescents with major depressive disorder and 66 normal adolescents were given dextroamphetamine, 0.15 mg/kg, intravenously. Their cortisol, growth hormone, and prolactin responses were measured. These endocrine responses did not reliably distinguish adolescents with major depressive disorder from those without it, nor did they reliably delineate any specific depressive subgroup. These findings are compared with those from similar studies of adult depression.

Original languageEnglish (US)
Pages (from-to)415-422
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume30
Issue number3
DOIs
StatePublished - Jan 1 1991

Keywords

  • adolescence
  • amphetamine
  • depression
  • neuroendocrine

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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    WATERMAN, G. SCOTT., RYAN, NEAL. D., PUIG-ANTICH, JOAQUIM., MEYER, VIVECA., AMBROSINI, PAUL. J., RABINOVICH, HARRIS., STULL, STACY., NOVACENKO, HANA., WILLIAMSON, DOUGLAS. E., & NELSON, BEVERLY. (1991). Hormonal Responses to Dextroamphetamine in Depressed and Normal Adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 30(3), 415-422. https://doi.org/10.1097/00004583-199105000-00010