Hormonal regulation of benzo[a]pyrene metabolism in human adrenocortical cell cultures

Peter J. Hornsby, Sandra E. Harris, Kathy A. Aldern

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

In cultured fetal human adrenocortical cells, metabolism of the carcinogen benzo[a]pyrene was found to be unresponsive to the xenobiotic inducers 3-methylcholanthrene, benz[a]anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. However, exposure of cultures to the hormone adrenocorticotropin (ACTH) for 48 hours stimulated benzo[a]pyrene metabolism 3-fold. The major metabolite was the 7,8-diol. Other compounds which stimulate the production of adrenocortical cell cyclic AMP (forskolin and cholera toxin) as well as monobutyryl cyclic AMP also increased benzo[a]pyrene metabolism. Human adrenocortical cells thus provide an unusual example of hormonal regulation of the metabolism of a carcinogen.

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume131
Issue number1
DOIs
StatePublished - Aug 30 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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