Hormonal modulation of pineal melatonin synthesis in rats and syrian hamsters: Effects of adrenalectomy and corticosteroid implants

T. H. Champney, Cheryl M. Craft, Susan M. Webb, R. J. Reiter

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Pineal levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid and the activities of the enzymes N-acetyltransferase and hydroxyindole-O-methyltransferase were determined in male albino rats and Syrian hamsters that were implanted with the appropriate corticosteroid or adrenalectomized two weeks earlier. Melatonin content and NAT activity were increased at 4 hours (during darkness) in adrenalectomized hamsters; conversely, no alterations in melatonin levels were observed in either adrenalectomized or implanted rats. It is suggested that the changes in adrenal function probably have a minor influence on pineal melatonin production.

Original languageEnglish (US)
Pages (from-to)67-79
Number of pages13
JournalJournal of Neural Transmission
Volume64
Issue number1
DOIs
Publication statusPublished - Mar 1 1985

    Fingerprint

Keywords

  • Pineal
  • corticosterone
  • cortisol adrenalectomy
  • melatonin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this