Hormonal changes in burned hamsters

Mary K. Vaughan; George M. Vaughan; Khan Z. Shirani; Basil A. Pruitt; Arthur D. Mason

doi:10.1210/endo-117-3-1090

Hormonal changes in burned hamsters

Mary K. Vaughan, George M. Vaughan, Khan Z. Shirani, Basil A. Pruitt, Arthur D. Mason

Department of Surgery

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Burned male Syrian hamsters (burn size 23% of body surface) exhibited reduced total (T₄) and free (FT₄) serum concentrations, a defect in T₄ binding to serum proteins manifested by the T₄ dialyzable fraction but not the in vitro T₃ charcoal uptake, and reduced serum testosterone concentration. These changes are similar to those noted previously in burned humans. Unlike such patients, burned hamsters did not exhibit reduced serum T₃ nor elevated rT₃ concentrations in a reproducible manner. Pinealectomy performed before burning in hamsters did not prevent the burn-induced depression in serum T₄ and testosterone.

Original language	English (US)
Pages (from-to)	1090-1095
Number of pages	6
Journal	Endocrinology
Volume	117
Issue number	3
DOIs	https://doi.org/10.1210/endo-117-3-1090
State	Published - Sep 1985

ASJC Scopus subject areas

Endocrinology

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title = "Hormonal changes in burned hamsters",

abstract = "Burned male Syrian hamsters (burn size 23% of body surface) exhibited reduced total (T4) and free (FT4) serum concentrations, a defect in T4 binding to serum proteins manifested by the T4 dialyzable fraction but not the in vitro T3 charcoal uptake, and reduced serum testosterone concentration. These changes are similar to those noted previously in burned humans. Unlike such patients, burned hamsters did not exhibit reduced serum T3 nor elevated rT3 concentrations in a reproducible manner. Pinealectomy performed before burning in hamsters did not prevent the burn-induced depression in serum T4 and testosterone.",

author = "Vaughan, {Mary K.} and Vaughan, {George M.} and Shirani, {Khan Z.} and Pruitt, {Basil A.} and Mason, {Arthur D.}",

year = "1985",

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doi = "10.1210/endo-117-3-1090",

language = "English (US)",

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AU - Vaughan, Mary K.

AU - Vaughan, George M.

AU - Shirani, Khan Z.

AU - Pruitt, Basil A.

AU - Mason, Arthur D.

PY - 1985/9

Y1 - 1985/9

N2 - Burned male Syrian hamsters (burn size 23% of body surface) exhibited reduced total (T4) and free (FT4) serum concentrations, a defect in T4 binding to serum proteins manifested by the T4 dialyzable fraction but not the in vitro T3 charcoal uptake, and reduced serum testosterone concentration. These changes are similar to those noted previously in burned humans. Unlike such patients, burned hamsters did not exhibit reduced serum T3 nor elevated rT3 concentrations in a reproducible manner. Pinealectomy performed before burning in hamsters did not prevent the burn-induced depression in serum T4 and testosterone.

AB - Burned male Syrian hamsters (burn size 23% of body surface) exhibited reduced total (T4) and free (FT4) serum concentrations, a defect in T4 binding to serum proteins manifested by the T4 dialyzable fraction but not the in vitro T3 charcoal uptake, and reduced serum testosterone concentration. These changes are similar to those noted previously in burned humans. Unlike such patients, burned hamsters did not exhibit reduced serum T3 nor elevated rT3 concentrations in a reproducible manner. Pinealectomy performed before burning in hamsters did not prevent the burn-induced depression in serum T4 and testosterone.

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Hormonal changes in burned hamsters

Abstract

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