Holding hands to halt malaria: stronger together through heterotypic antibody interactions

Evelien M. Bunnik; Sebastiaan Bol; Gregory C. Ippolito

doi:10.1016/j.pt.2025.04.004

Holding hands to halt malaria: stronger together through heterotypic antibody interactions

Evelien M. Bunnik
, Sebastiaan Bol
, Gregory C. Ippolito

Research output: Contribution to journal › Short survey › peer-review

Abstract

Erythrocyte invasion by the malaria-causing parasite Plasmodium falciparum can be inhibited by antibodies against apical membrane antigen 1 (AMA1). Patel et al. identified two human anti-AMA1 monoclonal antibodies, one of which has strain-transcending neutralizing activity. Lateral interactions between the two antibodies improved their binding kinetics and inhibitory activity.

Original language	English (US)
Pages (from-to)	337-338
Number of pages	2
Journal	Trends in Parasitology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1016/j.pt.2025.04.004
State	Published - May 2025
Externally published	Yes

Keywords

AMA1
antibody neutralization
antibody synergy
monoclonal antibody
parasite invasion
vaccine development

ASJC Scopus subject areas

Parasitology
Infectious Diseases

Access to Document

10.1016/j.pt.2025.04.004

Cite this

@article{2422017a1a3943858bd5b7bdeee656b7,

title = "Holding hands to halt malaria: stronger together through heterotypic antibody interactions",

abstract = "Erythrocyte invasion by the malaria-causing parasite Plasmodium falciparum can be inhibited by antibodies against apical membrane antigen 1 (AMA1). Patel et al. identified two human anti-AMA1 monoclonal antibodies, one of which has strain-transcending neutralizing activity. Lateral interactions between the two antibodies improved their binding kinetics and inhibitory activity.",

keywords = "AMA1, antibody neutralization, antibody synergy, monoclonal antibody, parasite invasion, vaccine development",

author = "Bunnik, \{Evelien M.\} and Sebastiaan Bol and Ippolito, \{Gregory C.\}",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

month = may,

doi = "10.1016/j.pt.2025.04.004",

language = "English (US)",

volume = "41",

pages = "337--338",

journal = "Trends in Parasitology",

issn = "1471-4922",

publisher = "Elsevier Limited",

number = "5",

}

TY - JOUR

T1 - Holding hands to halt malaria

T2 - stronger together through heterotypic antibody interactions

AU - Bunnik, Evelien M.

AU - Bol, Sebastiaan

AU - Ippolito, Gregory C.

PY - 2025/5

Y1 - 2025/5

N2 - Erythrocyte invasion by the malaria-causing parasite Plasmodium falciparum can be inhibited by antibodies against apical membrane antigen 1 (AMA1). Patel et al. identified two human anti-AMA1 monoclonal antibodies, one of which has strain-transcending neutralizing activity. Lateral interactions between the two antibodies improved their binding kinetics and inhibitory activity.

AB - Erythrocyte invasion by the malaria-causing parasite Plasmodium falciparum can be inhibited by antibodies against apical membrane antigen 1 (AMA1). Patel et al. identified two human anti-AMA1 monoclonal antibodies, one of which has strain-transcending neutralizing activity. Lateral interactions between the two antibodies improved their binding kinetics and inhibitory activity.

KW - AMA1

KW - antibody neutralization

KW - antibody synergy

KW - monoclonal antibody

KW - parasite invasion

KW - vaccine development

UR - https://www.scopus.com/pages/publications/105003745227

UR - https://www.scopus.com/pages/publications/105003745227#tab=citedBy

U2 - 10.1016/j.pt.2025.04.004

DO - 10.1016/j.pt.2025.04.004

M3 - Short survey

C2 - 40268600

AN - SCOPUS:105003745227

SN - 1471-4922

VL - 41

SP - 337

EP - 338

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 5

ER -

Holding hands to halt malaria: stronger together through heterotypic antibody interactions

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this