Hodgkin-Huxley Models

F. Santamaria; J. M. Bower

doi:10.1016/B978-008045046-9.01413-3

Hodgkin-Huxley Models

F. Santamaria, J. M. Bower

Radiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Most theoretical and computational studies of neuronal function are based on a model for action potential generation developed more than 50, years ago by AL Hodgkin and AF Huxley. In this article, we review the historical and biophysical context that surrounded the creation of this model. We describe the fundamental properties of the Hodgkin and Huxley model, emphasizing its capability to replicate experimental results which it was not explicitly built to account for. Finally, we compare the original and modern physical interpretations of the model and briefly discuss its limitations and other alternative models.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	1173-1180
Number of pages	8
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.01413-3
State	Published - 2009

Keywords

Action potential
Biophysics
Computer models
Ion channels
Threshold

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/B978-008045046-9.01413-3

Cite this

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AB - Most theoretical and computational studies of neuronal function are based on a model for action potential generation developed more than 50, years ago by AL Hodgkin and AF Huxley. In this article, we review the historical and biophysical context that surrounded the creation of this model. We describe the fundamental properties of the Hodgkin and Huxley model, emphasizing its capability to replicate experimental results which it was not explicitly built to account for. Finally, we compare the original and modern physical interpretations of the model and briefly discuss its limitations and other alternative models.

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KW - Biophysics

KW - Computer models

KW - Ion channels

KW - Threshold

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EP - 1180

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -

Hodgkin-Huxley Models

Abstract

Keywords

ASJC Scopus subject areas

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