Hodgkin-Huxley Models

F. Santamaria, J. M. Bower

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Most theoretical and computational studies of neuronal function are based on a model for action potential generation developed more than 50, years ago by AL Hodgkin and AF Huxley. In this article, we review the historical and biophysical context that surrounded the creation of this model. We describe the fundamental properties of the Hodgkin and Huxley model, emphasizing its capability to replicate experimental results which it was not explicitly built to account for. Finally, we compare the original and modern physical interpretations of the model and briefly discuss its limitations and other alternative models.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages8
ISBN (Print)9780080450469
StatePublished - 2009


  • Action potential
  • Biophysics
  • Computer models
  • Ion channels
  • Threshold

ASJC Scopus subject areas

  • Neuroscience(all)


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