HLA‐linked genetic markers in Chinese and other Oriental populations

Peggy Miniter, Ka Wah Chan, Marilyn S. Pollack, Bo Dupont, Geoffrey J. O'Neill

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The polymorphic variants of the HLA‐linked genetic markers Bf, C2, C4 and GLO—I were studied in three mongoloid populations. Analysis of linkage disequilibrium between these markers and HLA‐A, B, C and DR antigens was carried out on test results from 140 unrelated Chinese individuals. The phenotypes BfS and GLO‐2 were found at significantly higher frequencies than in Caucasians. BfS was associated with B12 in Japanese but not in Chinese. A single individual with the rare Bf variant SI was found. No C2 deficient individuals were observed. The C2C (common) allele occurred at a gene frequency of 0.949 and the more basic allele C2B at 0.039. The acidic variant, C2A, was observed at a frequency of 0.011 and appeared to be associated with BfF. Eighty‐nine per cent of the Chinese were phenotypically C4FS. In contrast to Bf and C2, each of which is coded for by codominant alleles at a single genetic locus, C4 is coded for by two genes, C4F (Rodgers) and C4S (Chido). The C4F locus allele, C4F1 (extra fast), was strongly associated with HLA‐B17, as has been found in other populations, but a new association of the C4S locus deficiency allele, C4s° (Ch‐), with B17 was also observed. All HLA‐B17;C4s° haplotypes were BfS positive. As has been previously found in Caucasian populations, individuals of the C4F phenotype (i.e. genotypically Fs°Fs°) were all found to be Chido negative. The frequencies of the various HLA‐linked genetic markers, however, as much as the frequencies and associations of the HLA antigens themselves, distinguish these populations from other ethnic groups.

Original languageEnglish (US)
Pages (from-to)285-298
Number of pages14
JournalTissue Antigens
Volume18
Issue number5
DOIs
StatePublished - Nov 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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