HLA Genotyping in Family Members and Patients with Familial Polycystic Ovarian Disease

Fred P. Mandel, R. Jeffrey Chang, B. Dupont, Marilyn S. Pollack, Lenore S. Levine, Maria I. New, John K.H. Lu, Howard L. Judd

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

To determine whether the familial occurrence of polycystic ovarian disease (PCO) is related to the major histocompatibility complex (HLA), four families in whom at least two siblings had clinical evidence of disease were examined. The diagnosis of PCO was confirmed by increased serum testosterone, androstenedione, and LH levels compared to those in normal women. Elevated concentrations of dehydroepiandrosterone sulfate indicated excess adrenal androgen secretion. The result of HLA genotyping in the families studied demonstrate that PCO does not exhibit linkage to the HLA system.

Original languageEnglish (US)
Pages (from-to)862-864
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume56
Issue number4
DOIs
StatePublished - Apr 1983
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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