HLA antigen frequencies and HLA and Gm haplotype segregation in Filipino leprosy patients in Hawaii

M. S. Pollack, C. Ching, J. Pandey, E. Reichert

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Studies of 16 leprosy families and 11 additional unrelated Filipino leprosy patients in Hawaii confirm previous suggestions that there is a significant association of HLA DR2 (and MB1(now DQw1) with the lepromatous form of the disease, although the frequency of DR2 is very high in healthy Filipino controls. Preferential segregation of DR2 in children with the lepromatous form of the disease and the observed segregation of HLA haplotypes in children with either tuberculoid or lepromatous leprosy are consistent with the presence of a recessive, HLA-linked susceptibility (factor(s) with moderate penetrance; in families with 2 or more affected children, the patients share an excess of parental haplotypes. The segregation pattern of a very unusual Gm haplotype in 1 family further suggests that a Gm-linked susceptibility factor may also be involved.

Original languageEnglish (US)
Pages (from-to)119-129
Number of pages11
JournalDisease Markers
Volume3
Issue number2
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

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