HIV-associated renal disorders: recent insights into pathogenesis and treatment.

Ruth Berggren, Vecihi Batuman

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Renal electrolyte disorders, acute renal failure, and a variety of chronic renal diseases are common in HIV-infected patients. Glomerular disorders include IgA nephropathy, cryoglobulinemia, amyloidosis, and a lupus-like immune complex glomerulopathy. The most attention has been focused on collapsing glomerulopathy associated with nephrotic syndrome and progressive renal failure, which appears to be unique for patients with HIV/AIDS, called HIV-associated nephropathy (HIVAN), and it occurs predominantly in African American patients. Investigations in humans and in a transgenic mouse model reveal direct infection of renal epithelial cells by HIV and toxic cellular and immunologic processes mediated by HIV glycoproteins as the principal pathophysiology of HIVAN. Highly active antiretroviral treatment may be associated with an improved renal outcome and even reversal of kidney disease in some patients. Treatment with angiotensin-converting enzyme inhibitors may avert progression of HIVAN to end-stage kidney disease and result in superior patient and kidney survival as compared with untreated patients.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalCurrent HIV/AIDS reports
Volume2
Issue number3
DOIs
StatePublished - Aug 2005
Externally publishedYes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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