Abstract
HIV-1 infection of CD4-negative cells has been described both in vitro and in vivo. Two closely related glycolipids, galactosylceramide (GalCer) and 3′-sulfogalactosylceramide (GalS), have been proposed as potential alternative cellular receptors for HIV-1. Human adult cultured oligodendrocytes are CD4-negative/ GalCer-positive cells that are infected by HIV-1 in vitro, resulting in the presence of stable HIV-1 DNA sequences and the production of virus [Albright et al., Virology, (1996) in press]. The in vivo relevance and the effects of HIV infection on oligodendrocyte biology need to be studied further.
Original language | English (US) |
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Pages (from-to) | 43-50 |
Number of pages | 8 |
Journal | Perspectives in Drug Discovery and Design |
Volume | 5 |
DOIs | |
State | Published - Jan 1 1996 |
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
- Organic Chemistry