HIV-1 infection of a CD4-negative primary cell type: The oligodendrocyte

Andrew V. Albright; Ehud Lavi; Michael O'Connor; Francisco González-Scarano

doi:10.1007/BF02174000

HIV-1 infection of a CD4-negative primary cell type: The oligodendrocyte

Andrew V. Albright, Ehud Lavi, Michael O'Connor, Francisco González-Scarano

Neurology

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2 Scopus citations

Abstract

HIV-1 infection of CD4-negative cells has been described both in vitro and in vivo. Two closely related glycolipids, galactosylceramide (GalCer) and 3′-sulfogalactosylceramide (GalS), have been proposed as potential alternative cellular receptors for HIV-1. Human adult cultured oligodendrocytes are CD4-negative/ GalCer-positive cells that are infected by HIV-1 in vitro, resulting in the presence of stable HIV-1 DNA sequences and the production of virus [Albright et al., Virology, (1996) in press]. The in vivo relevance and the effects of HIV infection on oligodendrocyte biology need to be studied further.

Original language	English (US)
Pages (from-to)	43-50
Number of pages	8
Journal	Perspectives in Drug Discovery and Design
Volume	5
DOIs	https://doi.org/10.1007/BF02174000
State	Published - Jan 1 1996

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Organic Chemistry

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abstract = "HIV-1 infection of CD4-negative cells has been described both in vitro and in vivo. Two closely related glycolipids, galactosylceramide (GalCer) and 3′-sulfogalactosylceramide (GalS), have been proposed as potential alternative cellular receptors for HIV-1. Human adult cultured oligodendrocytes are CD4-negative/ GalCer-positive cells that are infected by HIV-1 in vitro, resulting in the presence of stable HIV-1 DNA sequences and the production of virus [Albright et al., Virology, (1996) in press]. The in vivo relevance and the effects of HIV infection on oligodendrocyte biology need to be studied further.",

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AU - Albright, Andrew V.

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AU - González-Scarano, Francisco

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AB - HIV-1 infection of CD4-negative cells has been described both in vitro and in vivo. Two closely related glycolipids, galactosylceramide (GalCer) and 3′-sulfogalactosylceramide (GalS), have been proposed as potential alternative cellular receptors for HIV-1. Human adult cultured oligodendrocytes are CD4-negative/ GalCer-positive cells that are infected by HIV-1 in vitro, resulting in the presence of stable HIV-1 DNA sequences and the production of virus [Albright et al., Virology, (1996) in press]. The in vivo relevance and the effects of HIV infection on oligodendrocyte biology need to be studied further.

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HIV-1 infection of a CD4-negative primary cell type: The oligodendrocyte

Abstract

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