HIV-1 infection in a population-based twin sample

Keith Krasinski; Barbara J. Turner; Walter W. Hauck; Thomas R. Fanning

HIV-1 infection in a population-based twin sample

Keith Krasinski, Barbara J. Turner, Walter W. Hauck, Thomas R. Fanning

School of Nursing

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To examine factors associated with perinatal HIV-1 transmission among twins. Methods: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard (RH) of transmission. Results: In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status. Conclusions: These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal vital load is likely to have a greater impact than modifying delivery factors.

Original language	English (US)
Pages (from-to)	114-119
Number of pages	6
Journal	Pediatric AIDS and HIV Infection
Volume	8
Issue number	2
State	Published - 1997

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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abstract = "Objective: To examine factors associated with perinatal HIV-1 transmission among twins. Methods: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard (RH) of transmission. Results: In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status. Conclusions: These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal vital load is likely to have a greater impact than modifying delivery factors.",

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T1 - HIV-1 infection in a population-based twin sample

AU - Krasinski, Keith

AU - Turner, Barbara J.

AU - Hauck, Walter W.

AU - Fanning, Thomas R.

PY - 1997

Y1 - 1997

N2 - Objective: To examine factors associated with perinatal HIV-1 transmission among twins. Methods: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard (RH) of transmission. Results: In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status. Conclusions: These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal vital load is likely to have a greater impact than modifying delivery factors.

AB - Objective: To examine factors associated with perinatal HIV-1 transmission among twins. Methods: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard (RH) of transmission. Results: In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status. Conclusions: These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal vital load is likely to have a greater impact than modifying delivery factors.

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HIV-1 infection in a population-based twin sample

Abstract

ASJC Scopus subject areas

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