HIV-1 infection in a population-based twin sample

Keith Krasinski; Barbara J. Turner; Walter W. Hauck; Thomas R. Fanning

HIV-1 infection in a population-based twin sample

Keith Krasinski, Barbara J. Turner, Walter W. Hauck, Thomas R. Fanning

School of Nursing

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To examine factors associated with perinatal HIV-1 transmission among twins. Methods: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard (RH) of transmission. Results: In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status. Conclusions: These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal vital load is likely to have a greater impact than modifying delivery factors.

Original language	English (US)
Pages (from-to)	114-119
Number of pages	6
Journal	Pediatric AIDS and HIV Infection
Volume	8
Issue number	2
State	Published - 1997

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

Fingerprint Dive into the research topics of 'HIV-1 infection in a population-based twin sample'. Together they form a unique fingerprint.

Cite this

@article{7ef53c8f61464ca88c0b38346f080d92,

title = "HIV-1 infection in a population-based twin sample",

abstract = "Objective: To examine factors associated with perinatal HIV-1 transmission among twins. Methods: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard (RH) of transmission. Results: In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status. Conclusions: These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal vital load is likely to have a greater impact than modifying delivery factors.",

author = "Keith Krasinski and Turner, {Barbara J.} and Hauck, {Walter W.} and Fanning, {Thomas R.}",

year = "1997",

language = "English (US)",

volume = "8",

pages = "114--119",

journal = "Pediatric AIDS and HIV Infection",

issn = "1045-5418",

publisher = "Mary Ann Liebert Inc.",

number = "2",

}

TY - JOUR

T1 - HIV-1 infection in a population-based twin sample

AU - Krasinski, Keith

AU - Turner, Barbara J.

AU - Hauck, Walter W.

AU - Fanning, Thomas R.

PY - 1997

Y1 - 1997

N2 - Objective: To examine factors associated with perinatal HIV-1 transmission among twins. Methods: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard (RH) of transmission. Results: In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status. Conclusions: These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal vital load is likely to have a greater impact than modifying delivery factors.

AB - Objective: To examine factors associated with perinatal HIV-1 transmission among twins. Methods: We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard (RH) of transmission. Results: In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status. Conclusions: These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal vital load is likely to have a greater impact than modifying delivery factors.

UR - http://www.scopus.com/inward/record.url?scp=0030906778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030906778&partnerID=8YFLogxK

M3 - Article

C2 - 11361777

AN - SCOPUS:0030906778

VL - 8

SP - 114

EP - 119

JO - Pediatric AIDS and HIV Infection

JF - Pediatric AIDS and HIV Infection

SN - 1045-5418

IS - 2

ER -