History of suffocation, state-trait anxiety, and anxiety sensitivity in predicting 35% carbon dioxide-induced panic

E. Serap Monkul, Elif Onur, Ümit Tural, John P. Hatch, Tunç Alkidotlessn, Baris Yücel, Hüray Fidaner

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The aim of this study was to examine the effects of history of suffocation, state-trait anxiety, and anxiety sensitivity on response to a 35% carbon dioxide (CO2) challenge in panic disorder patients, their healthy first-degree relatives and healthy comparisons. Thirty-two patients with panic disorder, 32 first-degree relatives, and 34 healthy volunteers underwent the 35% CO2 challenge. We assessed baseline anxiety with the Anxiety Sensitivity Index (ASI) and State-Trait Anxiety Inventory (STAI1), and panic symptoms with the Panic Symptom List (PSL III-R). A history of suffocation was associated with greater risk of CO2 reactivity in the combined sample. Patients had more anxiety sensitivity and state and trait anxiety than relatives and healthy comparisons; the difference between relatives and healthy comparisons was not significant. In female patients, trait anxiety predicted CO2-induced panic. Having a CO2-sensitive panic disorder patient as a first-degree relative did not predict CO2-induced panic in a healthy relative. History of suffocation may be an important predictor of CO2-induced panic. Trait anxiety may have a gender-specific relation to CO2 reactivity.

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalPsychiatry Research
Volume179
Issue number2
DOIs
StatePublished - Sep 1 2010

Keywords

  • Anxiety sensitivity
  • Carbon dioxide
  • First-degree relatives
  • Panic disorder
  • Suffocation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Monkul, E. S., Onur, E., Tural, Ü., Hatch, J. P., Alkidotlessn, T., Yücel, B., & Fidaner, H. (2010). History of suffocation, state-trait anxiety, and anxiety sensitivity in predicting 35% carbon dioxide-induced panic. Psychiatry Research, 179(2), 194-197. https://doi.org/10.1016/j.psychres.2009.06.015