History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis

Breno S. Diniz; Antonio L. Teixeira; Fei Cao; Ariel Gildengers; Jair C. Soares; Meryl A. Butters; Charles F. Reynolds

doi:10.1016/j.jagp.2016.11.014

History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis

Breno S. Diniz, Antonio L. Teixeira, Fei Cao, Ariel Gildengers, Jair C. Soares, Meryl A. Butters, Charles F. Reynolds

Research output: Contribution to journal › Review article › peer-review

126 Scopus citations

Abstract

Objective We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia. Methods We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis. Results History of BD significantly increased the risk of diagnosis of dementia (pooled odds ratio: 2.36; 95% confidence interval: 1.36–4.09; z = 3.07, p < 0.001). Evidence of heterogeneity and of publication bias in the analysis was found. Conclusion History of BD is associated with significantly higher risk of dementia in older adults. Future studies are necessary to evaluate the potential mediators of this association and to evaluate interventions that may reduce the risk of dementia in this population.

Original language	English (US)
Pages (from-to)	357-362
Number of pages	6
Journal	American Journal of Geriatric Psychiatry
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/j.jagp.2016.11.014
State	Published - Apr 1 2017
Externally published	Yes

Keywords

Alzheimer disease
Bipolar disorder
dementia
risk factor

ASJC Scopus subject areas

Geriatrics and Gerontology
Psychiatry and Mental health

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10.1016/j.jagp.2016.11.014

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title = "History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis",

abstract = "Objective We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia. Methods We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis. Results History of BD significantly increased the risk of diagnosis of dementia (pooled odds ratio: 2.36; 95% confidence interval: 1.36–4.09; z = 3.07, p < 0.001). Evidence of heterogeneity and of publication bias in the analysis was found. Conclusion History of BD is associated with significantly higher risk of dementia in older adults. Future studies are necessary to evaluate the potential mediators of this association and to evaluate interventions that may reduce the risk of dementia in this population.",

keywords = "Alzheimer disease, Bipolar disorder, dementia, risk factor",

author = "Diniz, {Breno S.} and Teixeira, {Antonio L.} and Fei Cao and Ariel Gildengers and Soares, {Jair C.} and Butters, {Meryl A.} and Reynolds, {Charles F.}",

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T2 - A Systematic Review and Meta-Analysis

AU - Diniz, Breno S.

AU - Teixeira, Antonio L.

AU - Cao, Fei

AU - Gildengers, Ariel

AU - Soares, Jair C.

AU - Butters, Meryl A.

AU - Reynolds, Charles F.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objective We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia. Methods We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis. Results History of BD significantly increased the risk of diagnosis of dementia (pooled odds ratio: 2.36; 95% confidence interval: 1.36–4.09; z = 3.07, p < 0.001). Evidence of heterogeneity and of publication bias in the analysis was found. Conclusion History of BD is associated with significantly higher risk of dementia in older adults. Future studies are necessary to evaluate the potential mediators of this association and to evaluate interventions that may reduce the risk of dementia in this population.

AB - Objective We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia. Methods We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis. Results History of BD significantly increased the risk of diagnosis of dementia (pooled odds ratio: 2.36; 95% confidence interval: 1.36–4.09; z = 3.07, p < 0.001). Evidence of heterogeneity and of publication bias in the analysis was found. Conclusion History of BD is associated with significantly higher risk of dementia in older adults. Future studies are necessary to evaluate the potential mediators of this association and to evaluate interventions that may reduce the risk of dementia in this population.

KW - Alzheimer disease

KW - Bipolar disorder

KW - dementia

KW - risk factor

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History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis

Abstract

Keywords

ASJC Scopus subject areas

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