History and prospects: Symposium on organisms with slow aging

C. E. Finch, S. N. Austad

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

We discuss the background concepts which lead to this issue of Experimental Gerontology. On one hand, genetic and molecular studies of short-lived worms, flies, and mice are yielding remarkable discoveries on gene systems that regulate the life span. On the other hand, little is known about the nature of aging in other vertebrates, with life spans extending into the human range or beyond the record 122y human life span, which may have aging processes that are so slow as to be 'negligible'. We point out that organisms with these vastly different life spans have essentially identical cells within an evolutionary group and that the cellular tool kit that existed by 600 million years ago allowed the evolution of life spans ranging up to one million-fold difference in length. The possibility of negligible senescence has not been widely discussed, and may be in conflict with mathematical deductions from population genetics theory. We propose minimal criteria for the lack of senescence: (1) no observable increase in age-specific mortality rate or decrease in reproduction rate after sexual maturity; and (2) no observable age-related decline in physiological capacity or disease resistance. We also introduce some of the species discussed in subsequent chapters which are unfamiliar models to most biomedical researchers.

Original languageEnglish (US)
Pages (from-to)593-597
Number of pages5
JournalExperimental Gerontology
Volume36
Issue number4-6
DOIs
StatePublished - Apr 18 2001

Keywords

  • Negligible senescence
  • Slow aging

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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