Histopathologic Patterns of Colitis in Patients with Impaired Renal Function

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Abstract

Objectives: To characterize the histopathologic features of colitis in patients with impaired renal function. Methods: We retrospectively identified 413 patients who underwent colonoscopic evaluation for colitis between 2011 and 2015. Patients were divided into four groups based on estimated glomerular filtrate rates. Patients with impaired renal function were compared to overall and age-matched patients with normal renal function. Results: Compared to a preponderance of inflammatory bowel disease (33%) and lymphocytic colitis (9.6%) in patients with normal renal function, ischemic colitis (58%) was the predominant histopathologic pattern in the patients with impaired renal function. Infectious colitis was the second most common pattern (20.8%), with Clostridium difficile and cytomegalovirus infections being more frequent. Medication-induced injury was the third most common pattern, with crystal-associated injury being the exclusive pattern found in this study. Conclusions: Colitis in patients with impaired renal function is etiologically distinct from that seen in patients with normal renal function.

Original languageEnglish (US)
Pages (from-to)380-386
Number of pages7
JournalAmerican journal of clinical pathology
Volume153
Issue number3
DOIs
StatePublished - Feb 8 2020

Keywords

  • Biopsy
  • Colitis histopathologic patterns
  • Crystal deposition
  • Impaired renal function
  • Ischemic colitis
  • Lower gastrointestinal tract
  • Medication-induced injury

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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