Histological and clinical evaluation of recombinant human platelet-derived growth factor combined with beta tricalcium phosphate for the treatment of human class III furcation defects

James T. Mellonig, Maria Del Pilar Valderrama, David L. Cochran

Research output: Contribution to journalArticle

23 Scopus citations


Four patients with chronic advanced periodonitits participated in this study At least one mandibular first molar had to have a hopeless periodontal and prosthetic prognosis. Clinical measurements were mde, and the furcation defects were surgically exposed. A notch was placed through the calculus on both the mesial and distal roots. the furcal aea was root planed with diamond-tip ultrasonic instruments. the furcations were grafted with a combination of recombinant human platelet-derived growth factor and beta tricalcium phoshate. A collagen barrier for guided tissue regeneration was used on both the facial and lingual surfaces. The flaps were coronally positioned and sutured. All patients were followed at 2-week intervals for 6 months. At 6 months, all teeth demonstrate areduction in probing depth and a gain in clinical attachment. One tooth demonstrated a Class II furcation involvement, while through-and-through furcation involvement was still evident on the other three experimental teeth. The teeth were removed en bloc and processed for histologic evaluation. Three root surfaces demonstrated periodontal regeneration, an additionla three showed new attachment and one surface revealed jnctionla epithelium as measured from the base of the calculus notch. The notch area could not be identified on one surface of one specimen.

Original languageEnglish (US)
Pages (from-to)169-177
Number of pages9
JournalInternational Journal of Periodontics and Restorative Dentistry
Issue number2
Publication statusPublished - Oct 26 2009


ASJC Scopus subject areas

  • Oral Surgery
  • Periodontics

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