TY - JOUR
T1 - Histological and clinical evaluation of recombinant human platelet-derived growth factor combined with beta tricalcium phosphate for the treatment of human class III furcation defects
AU - Mellonig, James T.
AU - Del Pilar Valderrama, Maria
AU - Cochran, David L.
PY - 2009
Y1 - 2009
N2 - Four patients with chronic advanced periodonitits participated in this study At least one mandibular first molar had to have a hopeless periodontal and prosthetic prognosis. Clinical measurements were mde, and the furcation defects were surgically exposed. A notch was placed through the calculus on both the mesial and distal roots. the furcal aea was root planed with diamond-tip ultrasonic instruments. the furcations were grafted with a combination of recombinant human platelet-derived growth factor and beta tricalcium phoshate. A collagen barrier for guided tissue regeneration was used on both the facial and lingual surfaces. The flaps were coronally positioned and sutured. All patients were followed at 2-week intervals for 6 months. At 6 months, all teeth demonstrate areduction in probing depth and a gain in clinical attachment. One tooth demonstrated a Class II furcation involvement, while through-and-through furcation involvement was still evident on the other three experimental teeth. The teeth were removed en bloc and processed for histologic evaluation. Three root surfaces demonstrated periodontal regeneration, an additionla three showed new attachment and one surface revealed jnctionla epithelium as measured from the base of the calculus notch. The notch area could not be identified on one surface of one specimen.
AB - Four patients with chronic advanced periodonitits participated in this study At least one mandibular first molar had to have a hopeless periodontal and prosthetic prognosis. Clinical measurements were mde, and the furcation defects were surgically exposed. A notch was placed through the calculus on both the mesial and distal roots. the furcal aea was root planed with diamond-tip ultrasonic instruments. the furcations were grafted with a combination of recombinant human platelet-derived growth factor and beta tricalcium phoshate. A collagen barrier for guided tissue regeneration was used on both the facial and lingual surfaces. The flaps were coronally positioned and sutured. All patients were followed at 2-week intervals for 6 months. At 6 months, all teeth demonstrate areduction in probing depth and a gain in clinical attachment. One tooth demonstrated a Class II furcation involvement, while through-and-through furcation involvement was still evident on the other three experimental teeth. The teeth were removed en bloc and processed for histologic evaluation. Three root surfaces demonstrated periodontal regeneration, an additionla three showed new attachment and one surface revealed jnctionla epithelium as measured from the base of the calculus notch. The notch area could not be identified on one surface of one specimen.
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M3 - Article
C2 - 19408479
AN - SCOPUS:67650218465
SN - 0198-7569
VL - 29
SP - 169
EP - 177
JO - International Journal of Periodontics and Restorative Dentistry
JF - International Journal of Periodontics and Restorative Dentistry
IS - 2
ER -