Histologic grading of prostatic adenocarcinoma can be further optimized

Jesse K. McKenney, Wei Wei, Sarah Hawley, Heidi Auman, Lisa F. Newcomb, Hilary D. Boyer, Ladan Fazli, Jeff Simko, Antonio Hurtado-Coll, Dean A. Troyer, Maria S. Tretiakova, Funda Vakar-Lopez, Peter R. Carroll, Matthew R. Cooperberg, Martin E. Gleave, Raymond S. Lance, Dan W. Lin, Peter S. Nelson, Ian M. Thompson, Lawrence D. TrueZiding Feng, James D. Brooks

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Histologic grading remains the gold standard for prognosis in prostate cancer, and assessment of Gleason score plays a critical role in active surveillance management. We sought to optimize the prognostic stratification of grading and developed a method of recording and studying individual architectural patterns by light microscopic evaluation that is independent of standard Gleason grade. Some of the evaluated patterns are not assessed by current Gleason grading (eg, reactive stromal response). Individual histologic patterns were correlated with recurrence-free survival in a retrospective postradical prostatectomy cohort of 1275 patients represented by the highest-grade foci of carcinoma in tissue microarrays. In univariable analysis, fibromucinous rupture with varied epithelial complexity had a significantly lower relative risk of recurrence-free survival in cases graded as 3+4=7. Cases having focal "poorly formed glands," which could be designated as pattern 3+4=7, had lower risk than cribriform patterns with either small cribriform glands or expansile cribriform growth. In separate multivariable Cox proportional hazard analyses of both Gleason score 3+3=6 and 3+4=7 carcinomas, reactive stromal patterns were associated with worse recurrence-free survival. Decision tree models demonstrate potential regrouping of architectural patterns into categories with similar risk. In summary, we argue that Gleason score assignment by current consensus guidelines are not entirely optimized for clinical use, including active surveillance. Our data suggest that focal poorly formed gland and cribriform patterns, currently classified as Gleason pattern 4, should be in separate prognostic groups, as the latter is associated with worse outcome. Patterns with extravasated mucin are likely overgraded in a subset of cases with more complex epithelial bridges, whereas stromogenic cancers have a worse outcome than conveyed by Gleason grade alone. These findings serve as a foundation to facilitate optimization of histologic grading and strongly support incorporating reactive stroma into routine assessment.

Original languageEnglish (US)
Pages (from-to)1439-1456
Number of pages18
JournalAmerican Journal of Surgical Pathology
Volume40
Issue number11
DOIs
StatePublished - Oct 1 2016

Keywords

  • Gleason
  • adenocarcinoma
  • cribriform
  • grade
  • mucin
  • prostate
  • stromal reaction
  • stromogenic

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Histologic grading of prostatic adenocarcinoma can be further optimized'. Together they form a unique fingerprint.

  • Cite this

    McKenney, J. K., Wei, W., Hawley, S., Auman, H., Newcomb, L. F., Boyer, H. D., Fazli, L., Simko, J., Hurtado-Coll, A., Troyer, D. A., Tretiakova, M. S., Vakar-Lopez, F., Carroll, P. R., Cooperberg, M. R., Gleave, M. E., Lance, R. S., Lin, D. W., Nelson, P. S., Thompson, I. M., ... Brooks, J. D. (2016). Histologic grading of prostatic adenocarcinoma can be further optimized. American Journal of Surgical Pathology, 40(11), 1439-1456. https://doi.org/10.1097/PAS.0000000000000736