Histologic evaluation of wound healing after ridge preservation with cortical, cancellous, and combined cortico-cancellous freeze-dried bone allograft: A randomized controlled clinical trial

Randy S. Demetter, Blaine G. Calahan, Brian L. Mealey

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

bone allografts (FDBA) are available for use in alveolar ridge preservation after tooth extraction. There are currently no data regarding use of a combination 50%/50% corticocancellous FDBA compared with a 100% cortical or 100% cancellous FDBA in ridge preservation. The primary objective of this study is to dimensionally and histologically evaluate healing after ridge preservation in non-molar sites using 50%/50% cortico-cancellous FDBA versus 100% cortical and 100% cancellous FDBA. Methods: Sixty-six patients requiring extraction of a nonmolar tooth were enrolled and randomized into three groups to receive ridge preservation with the following: 1) 100% cortical FDBA; 2) 100% cancellous FDBA; or 3) 50%/50% cortico-cancellous FDBA. After 18 to 20 weeks of healing, a biopsy was harvested, and an implant was placed. The alveolar ridge was measured pre-and postoperatively to evaluate change in ridge height and width. Percentages of vital bone, residual graft, and connective tissue (CT)/other were determined via histomorphometric analysis. Results: Histomorphometric analysis revealed no significant differences among groups regarding percentage of vital bone or CT/other. The 100% cortical FDBA group had significantly greater residual graft material (P = 0.04). Dimensional analysis revealed no significant between-group differences in any parameter measured. Conclusion: To the best knowledge of the authors, this study offers the first histologic evidence demonstrating no significant difference in vital bone formation or dimensional changes among 50%/50% cortico-cancellous FDBA, 100% cortical FDBA, and 100% cancellous FDBA when used in ridge preservation of non-molar tooth sites. J Periodontol 2017;88:860-868.

Original languageEnglish (US)
Pages (from-to)860-868
Number of pages9
JournalJournal of periodontology
Volume88
Issue number9
DOIs
StatePublished - Sep 2017

Keywords

  • Alveolar bone grafting
  • Alveolar bone loss
  • Bone resorption
  • Bone transplantation
  • Dental implants
  • Tooth extraction

ASJC Scopus subject areas

  • Periodontics

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