TY - JOUR
T1 - Histologic Evaluation of Acellular Dermal Matrix Allografts in Humans
AU - Owens, Jessica L.
AU - Cordell, Kitrina G.
AU - Amornporncharoen, Manrat
AU - Palaiologou, A. Archontia
N1 - Publisher Copyright:
© 2017 American Academy of Periodontology.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - INTRODUCTION: Acellular dermal matrix (ADM) is a cell-free dermal matrix comprised of a structurally integrated basement membrane complex and extracellular matrix in which collagen bundles and elastic fibers are the main components. There are several commercially available ADM allografts that have different processing methods. This case series reports the histologic presentation of two of the most widely used ADM allografts, referred to as ADM-A and ADM-B, in patients that had specific situations involving reentry. CASE SERIES: Two patients referred to the Louisiana State University Department of Periodontics, New Orleans, Louisiana, with 1- to 3-mm recession of at least two non-contiguous sites needing soft tissue augmentation, were treated with appropriate mucogingival procedures using ADM-A or ADM-B. After ≈6 to 8 months of healing, and due to clinical findings that necessitated further periodontal procedures, small tissue biopsies were obtained and examined microscopically. CONCLUSIONS: All samples of ADM (A and B) analyzed after staining with hematoxylin and eosin had a generally similar appearance under light microscopic examination, which suggests they are both well incorporated into native tissues after 6 to 8 months of healing. When stained with Verhoeff-Van Gieson, all samples showed elastin fibers, a finding consistent with previously published light microscopic observations of ADM. There appeared to be a more densely packed elastin pattern in the deep base of ADM-A compared with ADM-B. This might be an indication these two materials have a different healing pathway when used to augment the oral mucosa.
AB - INTRODUCTION: Acellular dermal matrix (ADM) is a cell-free dermal matrix comprised of a structurally integrated basement membrane complex and extracellular matrix in which collagen bundles and elastic fibers are the main components. There are several commercially available ADM allografts that have different processing methods. This case series reports the histologic presentation of two of the most widely used ADM allografts, referred to as ADM-A and ADM-B, in patients that had specific situations involving reentry. CASE SERIES: Two patients referred to the Louisiana State University Department of Periodontics, New Orleans, Louisiana, with 1- to 3-mm recession of at least two non-contiguous sites needing soft tissue augmentation, were treated with appropriate mucogingival procedures using ADM-A or ADM-B. After ≈6 to 8 months of healing, and due to clinical findings that necessitated further periodontal procedures, small tissue biopsies were obtained and examined microscopically. CONCLUSIONS: All samples of ADM (A and B) analyzed after staining with hematoxylin and eosin had a generally similar appearance under light microscopic examination, which suggests they are both well incorporated into native tissues after 6 to 8 months of healing. When stained with Verhoeff-Van Gieson, all samples showed elastin fibers, a finding consistent with previously published light microscopic observations of ADM. There appeared to be a more densely packed elastin pattern in the deep base of ADM-A compared with ADM-B. This might be an indication these two materials have a different healing pathway when used to augment the oral mucosa.
KW - Acellular dermis
KW - allografts
KW - connective tissue
KW - elastin
KW - gingival recession
KW - mouth mucosa
UR - http://www.scopus.com/inward/record.url?scp=85088352219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088352219&partnerID=8YFLogxK
U2 - 10.1902/cap.2017.160057
DO - 10.1902/cap.2017.160057
M3 - Article
C2 - 32689743
AN - SCOPUS:85088352219
SN - 2573-8046
VL - 7
SP - 122
EP - 127
JO - Clinical advances in periodontics
JF - Clinical advances in periodontics
IS - 3
ER -