Histologic and hormonal documentation of the luteinized unruptured follicle syndrome

Robert S. Schenken, Lawrence B. Werlin, Robert F. Williams, Thomas J. Prihoda, Gary D. Hodgen

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19 Scopus citations


Histologic and hormonal documentation of a luteinized unruptured follicle that occurred during a spontaneous menstrual cycle in a rhesus monkey is presented. Frequent (every 2 hours) blood sampling to assess midcycle hormonal dynamics in the monkey with the luteinized unruptured follicle and in five monkeys with an ovulatory stigma revealed significant aberrations in the gonadotropin and steroid hormone profiles associated with a luteinized unruptured follicle. Although the midcycle 17β-estradiol surge was normal, the monkey with the luteinized unruptured follicle demonstrated (1) blunted midcycle bioassayable luteinizing hormone, immunoassayable luteinizing hormone, and follicle-stimulating hormone surges; (2) absence of disparity in the bioassayable luteinizing hormone: immunoassayable luteinizing hormone ratio during the gonadotropin surge; (3) absence of progesterone and 17α-hydroxyprogesterone secretion during the gonadotropin surge; and (4) delayed and blunted rise in progesterone and 17α-hydroxyprogesterone after the gonadotropin surge. These findings suggest that an impaired luteinizing hormone surge, perhaps mediated by insufficient midcycle progestin secretion, is one possible cause of the luteinized unruptured follicle syndrome.

Original languageEnglish (US)
Pages (from-to)839-847
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
StatePublished - Apr 1986



  • Luteinized unruptured follicle
  • impaired luteinizing hormone surge
  • midcycle progestin secretion
  • ovulatory stigma

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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