Histiocytosis X: Response to Vinblastine Sulfate

Jerome S. Siegel, Charles A. Coltman

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17 Scopus citations


The designation histiocytosis X was coined as a unifying diagnostic term by Lichtenstein to draw attention to the pathological unity made up of several diverse and transitional syndromes, ie, eosinophilic xanthomatous granuloma, Hand-Schüller-Christian syndrome and Letterer-Siwe disease. Lichtenstein preferred the terms localized, chronic disseminated, and acute disseminated histiocytosis X to represent these related entities. A 40-year-old white man presented with localized histiocytosis X which progressed to a chronic disseminated form of the disease that could not be distinguished from Hand-Schüller-Christian disease. Almost complete resolution of this very resistant tumor occurred following treatment with vinblastine sulfate.

Original languageEnglish (US)
Pages (from-to)403-406
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Issue number6
StatePublished - Aug 8 1966
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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