Hippo Signaling Pathway in Pancreas Development

Yifan Wu, Pauline Aegerter, Michael Nipper, Logan Ramjit, Jun Liu, Pei Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

The Hippo signaling pathway is a vital regulator of pancreatic development and homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular plasticity. Through loss-of-function research, Hippo signaling has been found to play key roles in maintaining the proper balance between progenitor cell renewal, proliferation, and differentiation in pancreatic organogenesis. Other studies suggest that overactivation of YAP, a downstream effector of the pathway, promotes ductal cell development and suppresses endocrine cell fate specification via repression of Ngn3. After birth, disruptions in Hippo signaling have been found to lead to de-differentiation of acinar cells and pancreatitis-like phenotype. Further, Hippo signaling directs pancreatic morphogenesis by ensuring proper cell polarization and branching. Despite these findings, the mechanisms through which Hippo governs cell differentiation and pancreatic architecture are yet to be fully understood. Here, we review recent studies of Hippo functions in pancreatic development, including its crosstalk with NOTCH, WNT/β-catenin, and PI3K/Akt/mTOR signaling pathways.

Original languageEnglish (US)
Article number663906
JournalFrontiers in Cell and Developmental Biology
Volume9
DOIs
StatePublished - May 17 2021

Keywords

  • Hippo
  • LATS1/2
  • Mst1/2
  • YAP
  • development
  • pancreas

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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