Hilar/endobronchial NUT midline carcinoma: A case report

Deepika Sirohi, Sumit Mamun, Jaishree Jagirdar

Research output: Contribution to journalArticlepeer-review


Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare aggressive tumor described in the midline in the chest and head and neck. Initially reported in younger individuals, it has subsequently been shown to have a wider age distribution. The defining feature of these tumors is its association with BRD-NUT rearrangements. Occasionally NMC has been observed in a non-midline location. This case report describes an unusual rapidly progressing non-midline hilar/endobronchial location of an NMC in a 34-year-old man. The clinical and histologic features were that of an undifferentiated neoplasm concerning for a small cell carcinoma or a lymphoma. A broad panel of immunohistochemical markers for carcinoma, lymphoma and melanoma were negative which led us to suspect a diagnosis of NMC. A positive immunostaining with p63 and NUT protein antigen confirmed the diagnosis. The p63 positivity and cytokeratin negativity suggest a primitive/precursor squamous cell derivation.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalHuman Pathology: Case Reports
StatePublished - Mar 1 2017


  • Hilar/endobronchial
  • Nuclear protein in testis midline carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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