Abstract
Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare aggressive tumor described in the midline in the chest and head and neck. Initially reported in younger individuals, it has subsequently been shown to have a wider age distribution. The defining feature of these tumors is its association with BRD-NUT rearrangements. Occasionally NMC has been observed in a non-midline location. This case report describes an unusual rapidly progressing non-midline hilar/endobronchial location of an NMC in a 34-year-old man. The clinical and histologic features were that of an undifferentiated neoplasm concerning for a small cell carcinoma or a lymphoma. A broad panel of immunohistochemical markers for carcinoma, lymphoma and melanoma were negative which led us to suspect a diagnosis of NMC. A positive immunostaining with p63 and NUT protein antigen confirmed the diagnosis. The p63 positivity and cytokeratin negativity suggest a primitive/precursor squamous cell derivation.
Original language | English (US) |
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Pages (from-to) | 43-46 |
Number of pages | 4 |
Journal | Human Pathology: Case Reports |
Volume | 7 |
DOIs | |
State | Published - Mar 1 2017 |
Keywords
- Hilar/endobronchial
- Nuclear protein in testis midline carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine