Hilar/endobronchial NUT midline carcinoma: A case report

Deepika Sirohi; Sumit Mamun; Jaishree Jagirdar

doi:10.1016/j.ehpc.2015.06.004

Hilar/endobronchial NUT midline carcinoma: A case report

Deepika Sirohi, Sumit Mamun, Jaishree Jagirdar

Department of Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare aggressive tumor described in the midline in the chest and head and neck. Initially reported in younger individuals, it has subsequently been shown to have a wider age distribution. The defining feature of these tumors is its association with BRD-NUT rearrangements. Occasionally NMC has been observed in a non-midline location. This case report describes an unusual rapidly progressing non-midline hilar/endobronchial location of an NMC in a 34-year-old man. The clinical and histologic features were that of an undifferentiated neoplasm concerning for a small cell carcinoma or a lymphoma. A broad panel of immunohistochemical markers for carcinoma, lymphoma and melanoma were negative which led us to suspect a diagnosis of NMC. A positive immunostaining with p63 and NUT protein antigen confirmed the diagnosis. The p63 positivity and cytokeratin negativity suggest a primitive/precursor squamous cell derivation.

Original language	English (US)
Pages (from-to)	43-46
Number of pages	4
Journal	Human Pathology: Case Reports
Volume	7
DOIs	https://doi.org/10.1016/j.ehpc.2015.06.004
State	Published - Mar 1 2017

Keywords

Hilar/endobronchial
Nuclear protein in testis midline carcinoma

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.ehpc.2015.06.004

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title = "Hilar/endobronchial NUT midline carcinoma: A case report",

abstract = "Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare aggressive tumor described in the midline in the chest and head and neck. Initially reported in younger individuals, it has subsequently been shown to have a wider age distribution. The defining feature of these tumors is its association with BRD-NUT rearrangements. Occasionally NMC has been observed in a non-midline location. This case report describes an unusual rapidly progressing non-midline hilar/endobronchial location of an NMC in a 34-year-old man. The clinical and histologic features were that of an undifferentiated neoplasm concerning for a small cell carcinoma or a lymphoma. A broad panel of immunohistochemical markers for carcinoma, lymphoma and melanoma were negative which led us to suspect a diagnosis of NMC. A positive immunostaining with p63 and NUT protein antigen confirmed the diagnosis. The p63 positivity and cytokeratin negativity suggest a primitive/precursor squamous cell derivation.",

keywords = "Hilar/endobronchial, Nuclear protein in testis midline carcinoma",

author = "Deepika Sirohi and Sumit Mamun and Jaishree Jagirdar",

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doi = "10.1016/j.ehpc.2015.06.004",

language = "English (US)",

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journal = "Human Pathology: Case Reports",

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T1 - Hilar/endobronchial NUT midline carcinoma

T2 - A case report

AU - Sirohi, Deepika

AU - Mamun, Sumit

AU - Jagirdar, Jaishree

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare aggressive tumor described in the midline in the chest and head and neck. Initially reported in younger individuals, it has subsequently been shown to have a wider age distribution. The defining feature of these tumors is its association with BRD-NUT rearrangements. Occasionally NMC has been observed in a non-midline location. This case report describes an unusual rapidly progressing non-midline hilar/endobronchial location of an NMC in a 34-year-old man. The clinical and histologic features were that of an undifferentiated neoplasm concerning for a small cell carcinoma or a lymphoma. A broad panel of immunohistochemical markers for carcinoma, lymphoma and melanoma were negative which led us to suspect a diagnosis of NMC. A positive immunostaining with p63 and NUT protein antigen confirmed the diagnosis. The p63 positivity and cytokeratin negativity suggest a primitive/precursor squamous cell derivation.

AB - Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare aggressive tumor described in the midline in the chest and head and neck. Initially reported in younger individuals, it has subsequently been shown to have a wider age distribution. The defining feature of these tumors is its association with BRD-NUT rearrangements. Occasionally NMC has been observed in a non-midline location. This case report describes an unusual rapidly progressing non-midline hilar/endobronchial location of an NMC in a 34-year-old man. The clinical and histologic features were that of an undifferentiated neoplasm concerning for a small cell carcinoma or a lymphoma. A broad panel of immunohistochemical markers for carcinoma, lymphoma and melanoma were negative which led us to suspect a diagnosis of NMC. A positive immunostaining with p63 and NUT protein antigen confirmed the diagnosis. The p63 positivity and cytokeratin negativity suggest a primitive/precursor squamous cell derivation.

KW - Hilar/endobronchial

KW - Nuclear protein in testis midline carcinoma

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JO - Human Pathology: Case Reports

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ER -

Hilar/endobronchial NUT midline carcinoma: A case report

Abstract

Keywords

ASJC Scopus subject areas

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