Highly polymorphic apolipoprotein A-IV locus in the baboon

R. E. Ferrell, B. Sepehrnia, M. I. Kamboh, J. L. VandeBerg

    Research output: Contribution to journalArticle

    16 Scopus citations

    Abstract

    Apolipoprotein A-IV is found in mesenteric lymph chylomicrons, very low density lipoprotein particles, high density lipoprotein particles, and in the lipoprotein-free fraction of plasma. Apolipoprotein A-IV is polymorphic in a variety of species including human, dog, and horse. Efforts to estimate the impact of apolipoprotein A-IV structural variation on quantitative lipid levels in humans have been limited by the low frequency of the less common alleles. In the baboon, Papio hamadryas anubis, we have found apolipoprotein A-IV to be highly variable a the protein level with five alleles appearing at polymorphic frequency. We have confirmed the autosomal codominant inheritance of these five alleles in pedigreed baboons. The babbon has been shown to be a suitable animal model for the study of atherosclerosis, and the existence of a common, multi-allele apolipoprotein A-IV polymorphism in the baboon may be useful in elucidating the role of apolipoprotein A-IV in lipid metabolism.

    Original languageEnglish (US)
    Pages (from-to)131-135
    Number of pages5
    JournalJournal of lipid research
    Volume31
    Issue number1
    StatePublished - 1990

    Keywords

    • Animal models
    • Genetics
    • Immunoblotting

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Cell Biology

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    Ferrell, R. E., Sepehrnia, B., Kamboh, M. I., & VandeBerg, J. L. (1990). Highly polymorphic apolipoprotein A-IV locus in the baboon. Journal of lipid research, 31(1), 131-135.