Highly efficient phosphors in cancer sensing and PDT

Brian G. Yust, Lawrence C. Mimun, Dhiraj K. Sardar, Gangadharan Ajith Kumar, Peter J. Hornsby, Jason Rocha

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Highly efficient upconverting phosphors (NaYF4) doped with erbium ions are bio-conjugated and used for cancer imaging and photodynamic therapy. Once they are conjugated, the particles are injected into mice to demonstrate that cancer imaging with a near-infrared excitation source is possible. Finally, the particles are also conjugated with a photosensitive molecule with strong absorption near the upconversion emission peak (∼ 550nm). The upconversion energy causes the photosensitive molecule to create highly reactive oxidative species, which puncture and kill the cell to which it is attached. These particles are then used in a mouse model, and the size of the tumors is modeled as a function of the dosage and duration of the photodynamic therapy.

Original languageEnglish (US)
Title of host publicationReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV
DOIs
StatePublished - Apr 16 2012
EventReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV - San Francisco, CA, United States
Duration: Jan 23 2012Jan 25 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8233
ISSN (Print)1605-7422

Other

OtherReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV
CountryUnited States
CitySan Francisco, CA
Period1/23/121/25/12

Keywords

  • NaMnF
  • NaYF
  • infrared photodynamic therapy
  • near-infrared to visible
  • upconversion imaging
  • upconverting nanoparticles

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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