Highbrow proteasome in high-throughput technology

Maria Gaczynska, Karl Rodriguez, Srividya Madabhushi, Pawel A. Osmulski

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Proteasome is a major protease of the ubiquitin-proteasome pathway involved in the regulation of practically all intracellular biochemical processes. The enzyme core is created by a heteromultimer of complex architecture built with multiple subunits arranged into a tube-like structure. The multiple active sites of diverse peptidase specificity are hidden inside the tube. Access to the interior is guarded by a gate formed by the N-termini of specialized subunits and by the attachment of additional multisubunit protein complexes controlling the enzymatic capabilities of the core. Proteasome, due to its Byzantine molecular architecture and equally sophisticated enzymatic mechanism, is by itself a fascinating biophysical object. Recently, the position of the protease advanced from an academically remarkable protein processor to a providential anticancer drug target and futuristic nanomachine. Proteomics studies actively shape our current understanding of the protease and direct the future applications of the proteasome in medicine.

Original languageEnglish (US)
Pages (from-to)115-127
Number of pages13
JournalExpert Review of Proteomics
Volume3
Issue number1
DOIs
StatePublished - Jul 7 2006

Keywords

  • Allostery
  • Nanobiology
  • Proteasome
  • Proteasome inhibitors
  • Proteolysis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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