Abstract
High‐affinity uptake of dopamine (DA), glutamate, and γ‐aminobutyric acid (GABA) was determined in crude synaptosomal preparations from neostriatal regions of rats 7, 17, and 27 months of age. Dopamine uptake was highest in rostral neostriatum, but no age‐related differences were detected. On the other hand, the high‐affinity uptake of both GABA and glutamate was increased with age. This may reflect astrocytic hypertrophy or hyperplasia, which have been reported to occur in the neostriatum during the aging process.
Original language | English (US) |
---|---|
Pages (from-to) | 1766-1768 |
Number of pages | 3 |
Journal | Journal of neurochemistry |
Volume | 43 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1984 |
Externally published | Yes |
Keywords
- Aging
- Dopamine
- Glutamate
- High‐affinity uptake
- Neostriatum
- γ‐Aminobutyric acid
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience