High‐Affinity Uptake of Neurotransmitters in Rat Neostriatum: Effects of Aging

Randy Strong, T. Samorajski, Zehava Gottesfeld

Research output: Contribution to journalArticle

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Abstract

High‐affinity uptake of dopamine (DA), glutamate, and γ‐aminobutyric acid (GABA) was determined in crude synaptosomal preparations from neostriatal regions of rats 7, 17, and 27 months of age. Dopamine uptake was highest in rostral neostriatum, but no age‐related differences were detected. On the other hand, the high‐affinity uptake of both GABA and glutamate was increased with age. This may reflect astrocytic hypertrophy or hyperplasia, which have been reported to occur in the neostriatum during the aging process.

Original languageEnglish (US)
Pages (from-to)1766-1768
Number of pages3
JournalJournal of Neurochemistry
Volume43
Issue number6
DOIs
StatePublished - Dec 1984

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Keywords

  • Aging
  • Dopamine
  • Glutamate
  • High‐affinity uptake
  • Neostriatum
  • γ‐Aminobutyric acid

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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