High-speed chronoamperometry to study kinetics and mechanisms for serotonin clearance in vivo

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations


Serotonin (5-HT) regulates many complex behaviors and physiological functions. These include mood, sleep, feeding and thermoregulation, to name but a few. As a result, dysregulation of 5-HT neurotransmission can have severe consequences. For example, reduced serotonin neurotransmission is thought to underlie such affective disorders as depression and anxiety (Owens and Nemeroff 1994; Nemeroff and Owens 2004) and predispose to addictive disorders such as alcoholism (McBride et al. 1993; Virkkunen and Linnoila 1997). In addition, the hyperserotonergic state resulting from high doses of substituted amphetamines such as 3,4- methylenedioxymethamphetamine (MDMA, “Ecstasy”) contributes to the “serotonin syndrome,” symptoms of which include agitation, high body temperature, tachycardia, convulsions, coma, and in some cases death (Hegadoren et al. 1999; Green et al. 2003). Given the clear importance of maintaining homeostatic 5-HT neurotransmission, the regulation of extracellular concentration of 5-HT has been the focus of intense study for the past several decades.

Original languageEnglish (US)
Title of host publicationElectrochemical Methods for Neuroscience
PublisherCRC Press
Number of pages19
ISBN (Electronic)9781420005868
ISBN (Print)0849340756, 9780849340758
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Neuroscience(all)
  • Social Sciences(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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