High-speed chronoamperometry to study kinetics and mechanisms for serotonin clearance in vivo

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

Serotonin (5-HT) regulates many complex behaviors and physiological functions. These include mood, sleep, feeding and thermoregulation, to name but a few. As a result, dysregulation of 5-HT neurotransmission can have severe consequences. For example, reduced serotonin neurotransmission is thought to underlie such affective disorders as depression and anxiety (Owens and Nemeroff 1994; Nemeroff and Owens 2004) and predispose to addictive disorders such as alcoholism (McBride et al. 1993; Virkkunen and Linnoila 1997). In addition, the hyperserotonergic state resulting from high doses of substituted amphetamines such as 3,4- methylenedioxymethamphetamine (MDMA, “Ecstasy”) contributes to the “serotonin syndrome,” symptoms of which include agitation, high body temperature, tachycardia, convulsions, coma, and in some cases death (Hegadoren et al. 1999; Green et al. 2003). Given the clear importance of maintaining homeostatic 5-HT neurotransmission, the regulation of extracellular concentration of 5-HT has been the focus of intense study for the past several decades.

Original languageEnglish (US)
Title of host publicationElectrochemical Methods for Neuroscience
PublisherCRC Press
Pages63-81
Number of pages19
ISBN (Electronic)9781420005868
ISBN (Print)0849340756, 9780849340758
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Neuroscience(all)
  • Social Sciences(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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