High resolution ct findings in miliary lung disease

Georgeann McGuinness, David P. Naidich, J. Jagirdar, Barry Leitman, Dorothy I. McCauley

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

High-resolution CT (HRCT) and chest radiographs were compared in nine patients with miliary lung disease. In all cases, miliary disease was documented to be infectious in etiology; six of these patients proved to be human immunodeficiency virus (HIV) positive. A mixture of both sharply and poorly defined 1-3 mm nodules was seen in all cases, many of the latter having an appearance indistinguishable from airspace nodules. Other features attributable to the presence of nodules included nodular interlobular septae, nodular irregularity of vessels, subpleural dots, and studded fissures. Diffuse intra- and interlobular septal thickening also proved common, seen in all but one case (91%). Based on limited HRCT-pathologic correlation, CT findings appear primarily to be due to granulomatous foci developing in a seemingly random distribution involving both pulmonary airspaces as well as the interstitium. It is concluded that in the appropriate clinical setting this constellation of findings is characteristic of miliary disease; the role of HRCT especially in the early diagnosis of miliary disease in HIV positive patients remains to be determined prospectively.

Original languageEnglish (US)
Pages (from-to)384-390
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume16
Issue number3
DOIs
StatePublished - Jan 1 1992

Keywords

  • Acquired immunodeficiency syndrome(AIDS)
  • Computed tomography
  • Cytomegalovirus
  • Diseases
  • Histoplasmosis
  • Lungs
  • Tuberculosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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