High lipoprotein-associated phospholipase A2 is a risk factor for recurrent coronary events in postinfarction patients

James P. Corsetti, David L. Rainwater, Arthur J. Moss, Wojciech Zareba, Charles E. Sparks

    Research output: Contribution to journalArticle

    72 Scopus citations

    Abstract

    Background: Recent studies demonstrate that lipoprotein-associated phospholipase A2 (Lp-PLA2) is a risk factor for cardiovascular disease presumably deriving from generation of proinflammatory and proatherogenic species through its hydrolytic activity on lipoprotein-associated phospholipids. The goal of this study was to assess the relationship of Lp-PLA2 with a set of thrombogenic, lipid, inflammatory, and metabolic blood markers and to determine whether plasma Lp-PLA2 is a risk factor for recurrent coronary events in postinfarction patients. Methods: Factor analysis on the set of blood markers and Lp-PLA2 was performed for 766 patients of the Thrombogenic Factors and Recurrent Coronary Events (THROMBO) postinfarction study. Recurrent coronary event risk was assessed as a function of blood marker concentrations and Lp-PLA2 by Cox proportional hazards multivariable regression adjusted for significant clinical covariates. Results: Factor analysis revealed that Lp-PLA2 was associated with one factor dominated by cholesterol and apolipoprotein B and another factor dominated by HDL-cholesterol and triglycerides, with little association with an inflammatory factor dominated by C-reactive protein. Multivariable analysis demonstrated as significant and independent predictors of risk of secondary coronary events only apolipoprotein B in a model without Lp-PLA2 (hazard ratio, 1.66; 95% confidence interval, 1.14-2.40) and only Lp-PLA2 in a model with Lp-PLA 2 included [1.90 (1.31-2.75)]. Conclusions: Lp-PLA2 is a significant and independent predictor of risk for recurrent coronary events in postinfarction patients, and Lp-PLA2 is related to both hypercholesterolemia and high triglyceride-low HDL dyslipidemia in this study population.

    Original languageEnglish (US)
    Pages (from-to)1331-1338
    Number of pages8
    JournalClinical Chemistry
    Volume52
    Issue number7
    DOIs
    StatePublished - Jul 2006

    ASJC Scopus subject areas

    • Clinical Biochemistry
    • Biochemistry, medical

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