High levels of oral yeasts in early HIV-1 infection

C. A. Tylenda, J. Larsen, Chih-ko Yeh, H. C. Lane, P. C. Fox

Research output: Contribution to journalArticle

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Abstract

Ten human immunedeficiency virus-1 (HIV-1) infected homosexual or bisexual individuals (ages 24-45) with no history of opportunistic infection were examined, by culture, for the presence of yeasts in whole saliva and on oral mucosa. All were HIV-1 antibody-positive men, non-smokers, non-denture wearers, and taking no medication. The mean salivary level of yeast was four logs higher in the HIV-1 infected group compared to a control group of normal, unmedicated, non-smoking men (ages 20-41) who denied any risk behavior for HIV-1 infection. Identification of the yeast in these HIV-1 positive individuals established that Candida albicans was the predominant species found in whole saliva and on buccal mucosa and tongue. Distinct hyphae were observed with only one mucosal sample. No significant correlation was found between whole saliva yeast concentration and the T4/T8 lymphocyte ratios or absolute number of T4 cells. No correlation was observed between oral yeast concentration and anti-C. albicans IgA titers. The high level of oral yeast in these individuals prior to the development of opportunistic infections is consistent with the suggestion that oral defense mechanisms are compromised in individuals following HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)520-524
Number of pages5
JournalJournal of Oral Pathology and Medicine
Volume18
Issue number9
StatePublished - 1989
Externally publishedYes

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Virus Diseases
Yeasts
Saliva
CD4-Positive T-Lymphocytes
Viruses
Opportunistic Infections
Mouth Mucosa
Candida albicans
CD8-Positive T-Lymphocytes
CD4-CD8 Ratio
Hyphae
Defense Mechanisms
Risk-Taking
Tongue
Immunoglobulin A
Control Groups
Antibodies

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Tylenda, C. A., Larsen, J., Yeh, C., Lane, H. C., & Fox, P. C. (1989). High levels of oral yeasts in early HIV-1 infection. Journal of Oral Pathology and Medicine, 18(9), 520-524.

High levels of oral yeasts in early HIV-1 infection. / Tylenda, C. A.; Larsen, J.; Yeh, Chih-ko; Lane, H. C.; Fox, P. C.

In: Journal of Oral Pathology and Medicine, Vol. 18, No. 9, 1989, p. 520-524.

Research output: Contribution to journalArticle

Tylenda, CA, Larsen, J, Yeh, C, Lane, HC & Fox, PC 1989, 'High levels of oral yeasts in early HIV-1 infection', Journal of Oral Pathology and Medicine, vol. 18, no. 9, pp. 520-524.
Tylenda, C. A. ; Larsen, J. ; Yeh, Chih-ko ; Lane, H. C. ; Fox, P. C. / High levels of oral yeasts in early HIV-1 infection. In: Journal of Oral Pathology and Medicine. 1989 ; Vol. 18, No. 9. pp. 520-524.
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