High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis

Alda M S Silveira, Jeffrey Bethony, Andrea Gazzinelli, Helmut Kloos, Lúcia Alves De Oliveira Fraga, Maria Carolina B Álvares, Aluizio Prata, Henrique L. Guerra, Philip T Loverde, Rodrigo Correa-Oliveira, Giovanni Gazzinelli

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Specific IgG4 and IgE responses to adult worm antigen and soluble egg antigen (SEA) were examined in 267 individuals from an area in which schistosomiasis mansoni is endemic. Based on information obtained from clinical and sonographic examinations of this sample, the individuals were divided in three groups: 1) 204 individuals without periportal fibrosis, and liver and spleen enlargements; 2) 41 individuals without periportal fibrosis, but presenting with organopathy, with or without organomegaly; and 3) 22 individuals with periportal fibrosis, regardless of their status as having hepatomegaly and/or splenomegaly, Levels of IgG4 to SEA were significantly higher in sera from patients with fibrosis compared with the patients from the other two groups. We also found significantly higher levels of IgG4 against SEA in egg-negative patients with fibrosis compared with egg-negative patients from the other two groups. This report demonstrates a specific humoral response in patients presenting with initial fibrosis, a form of schistosomiasis transient between intestinal and severe hepatosplenic.

Original languageEnglish (US)
Pages (from-to)542-549
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume66
Issue number5
StatePublished - May 2002
Externally publishedYes

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Schistosoma mansoni
Ovum
Fibrosis
Immunoglobulin G
Antigens
Schistosomiasis mansoni
Hepatomegaly
Schistosomiasis
Splenomegaly
Liver Cirrhosis
Immunoglobulin E
Spleen
Serum

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Silveira, A. M. S., Bethony, J., Gazzinelli, A., Kloos, H., De Oliveira Fraga, L. A., Álvares, M. C. B., ... Gazzinelli, G. (2002). High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis. American Journal of Tropical Medicine and Hygiene, 66(5), 542-549.

High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis. / Silveira, Alda M S; Bethony, Jeffrey; Gazzinelli, Andrea; Kloos, Helmut; De Oliveira Fraga, Lúcia Alves; Álvares, Maria Carolina B; Prata, Aluizio; Guerra, Henrique L.; Loverde, Philip T; Correa-Oliveira, Rodrigo; Gazzinelli, Giovanni.

In: American Journal of Tropical Medicine and Hygiene, Vol. 66, No. 5, 05.2002, p. 542-549.

Research output: Contribution to journalArticle

Silveira, AMS, Bethony, J, Gazzinelli, A, Kloos, H, De Oliveira Fraga, LA, Álvares, MCB, Prata, A, Guerra, HL, Loverde, PT, Correa-Oliveira, R & Gazzinelli, G 2002, 'High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis', American Journal of Tropical Medicine and Hygiene, vol. 66, no. 5, pp. 542-549.
Silveira AMS, Bethony J, Gazzinelli A, Kloos H, De Oliveira Fraga LA, Álvares MCB et al. High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis. American Journal of Tropical Medicine and Hygiene. 2002 May;66(5):542-549.
Silveira, Alda M S ; Bethony, Jeffrey ; Gazzinelli, Andrea ; Kloos, Helmut ; De Oliveira Fraga, Lúcia Alves ; Álvares, Maria Carolina B ; Prata, Aluizio ; Guerra, Henrique L. ; Loverde, Philip T ; Correa-Oliveira, Rodrigo ; Gazzinelli, Giovanni. / High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis. In: American Journal of Tropical Medicine and Hygiene. 2002 ; Vol. 66, No. 5. pp. 542-549.
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