@article{8e0eab9a026e4b0eae47ccfff6bb7491,
title = "High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia",
abstract = "In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population. We measured heritability of clearance rate by evaluating patients infected with identical or nonidentical parasite genotypes, using methods analogous to human twin studies. A substantial proportion (56%-58%) of the variation in clearance rate is explained by parasite genetics. This has 2 important implications: (1) selection with artemisinin derivatives will tend to drive resistance spread and (2) because heritability is high, the genes underlying parasite clearance rate may be identified by genome-wide association.",
author = "Anderson, {Tim J.C.} and Shalini Nair and Standwell Nkhorna and Williams, {Jeff T.} and Mallika Imwong and Poravuth Yi and Duong Socheat and Debashish Das and Kesinee Chotivanich and Day, {Nicholas P.J.} and White, {Nicholas J.} and Dondorp, {Arjen M.}",
note = "Funding Information: Financial support: Molecular work at Southwest Foundation for Biomedical Research was funded by National Institutes of Health (NIH) RO1 (grant AI48071 to T.J.C.A.) and conducted in facilities constructed with support from Research Facilities Improvement Program (grant C06 RR013556 from the National Center for Research Resources, NIH). The clinical studies received financial support from the Wellcome Trust of Great Britain (Major Overseas Programme–Thailand Unit Core Grant), the Li Ka Shing Foundation (grant B9RMXT0-2), and the World Health Organization through grants provided by the Bill and Melinda Gates Foundation (grant 48821) and USAID (umbrella grant AAG-G-00-99-00005). The funding organizations played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.",
year = "2010",
month = may,
day = "1",
doi = "10.1086/651562",
language = "English (US)",
volume = "201",
pages = "1326--1330",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "9",
}