High genetic divergence and recombination in Arenaviruses from the Americas

Angela M. Archer, Rebeca Rico-Hesse

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The rodent-borne Arenaviruses are divided into two major antigenic groups: the Old World and New World complexes. Of the 15 known New World arenaviruses, four (Junin, Machupo, Sabia, and Guanarito) have been associated with hemorrhagic fever in humans. It has been difficult to assess the pathogenic or epidemic potential of the remaining viruses and the threat of emerging disease. We obtained full-length small (S) segment sequence data, encoding the nucleoprotein (NP) and glycoprotein precursor (GPC), from all American arenaviruses to predict their evolutionary and functional relationships. Phylogenetic analysis of NP or GPC amino acid sequences from all New World arenaviruses revealed three lineages and that Tamiami and Whitewater Arroyo viruses were probably derived from a single recombinant progenitor. The results imply that arenaviruses have been evolving independently for a very long time, leading to very diverse groupings that do not correlate with geography, rodent host, or human epidemic potential.

Original languageEnglish (US)
Pages (from-to)274-281
Number of pages8
JournalVirology
Volume304
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Arenavirus
New World Arenaviruses
Genetic Recombination
Nucleoproteins
Rodentia
Glycoproteins
Viruses
Geography
Amino Acid Sequence
Fever

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

High genetic divergence and recombination in Arenaviruses from the Americas. / Archer, Angela M.; Rico-Hesse, Rebeca.

In: Virology, Vol. 304, No. 2, 2002, p. 274-281.

Research output: Contribution to journalArticle

Archer, Angela M. ; Rico-Hesse, Rebeca. / High genetic divergence and recombination in Arenaviruses from the Americas. In: Virology. 2002 ; Vol. 304, No. 2. pp. 274-281.
@article{da85c04a552a490b9df3e98229a0d755,
title = "High genetic divergence and recombination in Arenaviruses from the Americas",
abstract = "The rodent-borne Arenaviruses are divided into two major antigenic groups: the Old World and New World complexes. Of the 15 known New World arenaviruses, four (Junin, Machupo, Sabia, and Guanarito) have been associated with hemorrhagic fever in humans. It has been difficult to assess the pathogenic or epidemic potential of the remaining viruses and the threat of emerging disease. We obtained full-length small (S) segment sequence data, encoding the nucleoprotein (NP) and glycoprotein precursor (GPC), from all American arenaviruses to predict their evolutionary and functional relationships. Phylogenetic analysis of NP or GPC amino acid sequences from all New World arenaviruses revealed three lineages and that Tamiami and Whitewater Arroyo viruses were probably derived from a single recombinant progenitor. The results imply that arenaviruses have been evolving independently for a very long time, leading to very diverse groupings that do not correlate with geography, rodent host, or human epidemic potential.",
author = "Archer, {Angela M.} and Rebeca Rico-Hesse",
year = "2002",
doi = "10.1006/viro.2002.1695",
language = "English (US)",
volume = "304",
pages = "274--281",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - High genetic divergence and recombination in Arenaviruses from the Americas

AU - Archer, Angela M.

AU - Rico-Hesse, Rebeca

PY - 2002

Y1 - 2002

N2 - The rodent-borne Arenaviruses are divided into two major antigenic groups: the Old World and New World complexes. Of the 15 known New World arenaviruses, four (Junin, Machupo, Sabia, and Guanarito) have been associated with hemorrhagic fever in humans. It has been difficult to assess the pathogenic or epidemic potential of the remaining viruses and the threat of emerging disease. We obtained full-length small (S) segment sequence data, encoding the nucleoprotein (NP) and glycoprotein precursor (GPC), from all American arenaviruses to predict their evolutionary and functional relationships. Phylogenetic analysis of NP or GPC amino acid sequences from all New World arenaviruses revealed three lineages and that Tamiami and Whitewater Arroyo viruses were probably derived from a single recombinant progenitor. The results imply that arenaviruses have been evolving independently for a very long time, leading to very diverse groupings that do not correlate with geography, rodent host, or human epidemic potential.

AB - The rodent-borne Arenaviruses are divided into two major antigenic groups: the Old World and New World complexes. Of the 15 known New World arenaviruses, four (Junin, Machupo, Sabia, and Guanarito) have been associated with hemorrhagic fever in humans. It has been difficult to assess the pathogenic or epidemic potential of the remaining viruses and the threat of emerging disease. We obtained full-length small (S) segment sequence data, encoding the nucleoprotein (NP) and glycoprotein precursor (GPC), from all American arenaviruses to predict their evolutionary and functional relationships. Phylogenetic analysis of NP or GPC amino acid sequences from all New World arenaviruses revealed three lineages and that Tamiami and Whitewater Arroyo viruses were probably derived from a single recombinant progenitor. The results imply that arenaviruses have been evolving independently for a very long time, leading to very diverse groupings that do not correlate with geography, rodent host, or human epidemic potential.

UR - http://www.scopus.com/inward/record.url?scp=0036946482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036946482&partnerID=8YFLogxK

U2 - 10.1006/viro.2002.1695

DO - 10.1006/viro.2002.1695

M3 - Article

C2 - 12504568

AN - SCOPUS:0036946482

VL - 304

SP - 274

EP - 281

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -