High-dose montelukast exposures in a 3-year-old and a 5-year-old child

Douglas B. Cobb, Cynthia L. Abbott, William A. Watson, Miguel C. Fernández

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The leukotriene receptor antagonists (LTRAs) is a relatively new class of asthma medication with a lack of toxicity for unintentional poisoning situations. This makes it difficult to determine which exposures require aggressive decontamination or simple monitoring in the home setting; prompting the question, "What LTRA dose is likely to produce significant toxicity?" We report a case of an unintentional poisoning with 80 mg montelukast in a 3-y-o asthmatic child that was managed in the home with observation alone and a second case of untentional 135 mg montelukast poisoning in a 5-y-o asthmatic child managed in an emergency department. In both cases, symptoms were not observed. These cases and available literature suggest that doses < 4.5 mg/kg in children result in minimal toxicity.

Original languageEnglish (US)
Pages (from-to)91-92
Number of pages2
JournalVeterinary and Human Toxicology
Volume44
Issue number2
StatePublished - 2002

Fingerprint

montelukast
Poisoning
Leukotriene Antagonists
Toxicity
poisoning
leukotrienes
toxicity
antagonists
dosage
receptors
Decontamination
decontamination
asthma
drug therapy
Hospital Emergency Service
Asthma
Observation
case studies
Monitoring
monitoring

ASJC Scopus subject areas

  • veterinary(all)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Cobb, D. B., Abbott, C. L., Watson, W. A., & Fernández, M. C. (2002). High-dose montelukast exposures in a 3-year-old and a 5-year-old child. Veterinary and Human Toxicology, 44(2), 91-92.

High-dose montelukast exposures in a 3-year-old and a 5-year-old child. / Cobb, Douglas B.; Abbott, Cynthia L.; Watson, William A.; Fernández, Miguel C.

In: Veterinary and Human Toxicology, Vol. 44, No. 2, 2002, p. 91-92.

Research output: Contribution to journalArticle

Cobb, DB, Abbott, CL, Watson, WA & Fernández, MC 2002, 'High-dose montelukast exposures in a 3-year-old and a 5-year-old child', Veterinary and Human Toxicology, vol. 44, no. 2, pp. 91-92.
Cobb, Douglas B. ; Abbott, Cynthia L. ; Watson, William A. ; Fernández, Miguel C. / High-dose montelukast exposures in a 3-year-old and a 5-year-old child. In: Veterinary and Human Toxicology. 2002 ; Vol. 44, No. 2. pp. 91-92.
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