Abstract
The leukotriene receptor antagonists (LTRAs) is a relatively new class of asthma medication with a lack of toxicity for unintentional poisoning situations. This makes it difficult to determine which exposures require aggressive decontamination or simple monitoring in the home setting; prompting the question, "What LTRA dose is likely to produce significant toxicity?" We report a case of an unintentional poisoning with 80 mg montelukast in a 3-y-o asthmatic child that was managed in the home with observation alone and a second case of untentional 135 mg montelukast poisoning in a 5-y-o asthmatic child managed in an emergency department. In both cases, symptoms were not observed. These cases and available literature suggest that doses < 4.5 mg/kg in children result in minimal toxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-92 |
| Number of pages | 2 |
| Journal | Veterinary and Human Toxicology |
| Volume | 44 |
| Issue number | 2 |
| State | Published - 2002 |
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ASJC Scopus subject areas
- veterinary(all)
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
High-dose montelukast exposures in a 3-year-old and a 5-year-old child. / Cobb, Douglas B.; Abbott, Cynthia L.; Watson, William A.; Fernández, Miguel C.
In: Veterinary and Human Toxicology, Vol. 44, No. 2, 2002, p. 91-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-dose montelukast exposures in a 3-year-old and a 5-year-old child
AU - Cobb, Douglas B.
AU - Abbott, Cynthia L.
AU - Watson, William A.
AU - Fernández, Miguel C.
PY - 2002
Y1 - 2002
N2 - The leukotriene receptor antagonists (LTRAs) is a relatively new class of asthma medication with a lack of toxicity for unintentional poisoning situations. This makes it difficult to determine which exposures require aggressive decontamination or simple monitoring in the home setting; prompting the question, "What LTRA dose is likely to produce significant toxicity?" We report a case of an unintentional poisoning with 80 mg montelukast in a 3-y-o asthmatic child that was managed in the home with observation alone and a second case of untentional 135 mg montelukast poisoning in a 5-y-o asthmatic child managed in an emergency department. In both cases, symptoms were not observed. These cases and available literature suggest that doses < 4.5 mg/kg in children result in minimal toxicity.
AB - The leukotriene receptor antagonists (LTRAs) is a relatively new class of asthma medication with a lack of toxicity for unintentional poisoning situations. This makes it difficult to determine which exposures require aggressive decontamination or simple monitoring in the home setting; prompting the question, "What LTRA dose is likely to produce significant toxicity?" We report a case of an unintentional poisoning with 80 mg montelukast in a 3-y-o asthmatic child that was managed in the home with observation alone and a second case of untentional 135 mg montelukast poisoning in a 5-y-o asthmatic child managed in an emergency department. In both cases, symptoms were not observed. These cases and available literature suggest that doses < 4.5 mg/kg in children result in minimal toxicity.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036131374&partnerID=8YFLogxK
M3 - Article
C2 - 11931512
AN - SCOPUS:0036131374
VL - 44
SP - 91
EP - 92
JO - Veterinary and Human Toxicology
JF - Veterinary and Human Toxicology
SN - 0145-6296
IS - 2
ER -