High-dose montelukast exposures in a 3-year-old and a 5-year-old child

Douglas B. Cobb, Cynthia L. Abbott, William A. Watson, Miguel C. Fernández

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The leukotriene receptor antagonists (LTRAs) is a relatively new class of asthma medication with a lack of toxicity for unintentional poisoning situations. This makes it difficult to determine which exposures require aggressive decontamination or simple monitoring in the home setting; prompting the question, "What LTRA dose is likely to produce significant toxicity?" We report a case of an unintentional poisoning with 80 mg montelukast in a 3-y-o asthmatic child that was managed in the home with observation alone and a second case of untentional 135 mg montelukast poisoning in a 5-y-o asthmatic child managed in an emergency department. In both cases, symptoms were not observed. These cases and available literature suggest that doses < 4.5 mg/kg in children result in minimal toxicity.

Original languageEnglish (US)
Pages (from-to)91-92
Number of pages2
JournalVeterinary and Human Toxicology
Volume44
Issue number2
StatePublished - Apr 3 2002

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ASJC Scopus subject areas

  • Toxicology
  • veterinary(all)
  • Health, Toxicology and Mutagenesis

Cite this

Cobb, D. B., Abbott, C. L., Watson, W. A., & Fernández, M. C. (2002). High-dose montelukast exposures in a 3-year-old and a 5-year-old child. Veterinary and Human Toxicology, 44(2), 91-92.