High-dose loratadine exposure in a six-year-old child

Douglas B. Cobb, William A. Watson, Miguel C. Fernández

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Loratadine is a long-acting antihistamine indicated for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria in patients 6 years of age and older. The literature contains little information on high-dose loratadine exposures; as a consequence, poison centers are unsure of the loratadine dose that can be managed with observation and the dose that requires treatment. We report an intentional ingestion of 300 mg loratadine by a 6-y-old child that resulted in minor elevation of blood pressure and heart rate when managed with supportive care only. Further studies and case series are needed before a minimum toxic dose can be established.

Original languageEnglish (US)
Pages (from-to)163-164
Number of pages2
JournalVeterinary and Human Toxicology
Volume43
Issue number3
StatePublished - Jun 2001

ASJC Scopus subject areas

  • Toxicology
  • veterinary(all)
  • Health, Toxicology and Mutagenesis

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