High dietary salt amplifies osmoresponsiveness in vasopressin-releasing neurons

David I. Levi; Joshua C. Wyrosdic; Amirah Iman Hicks; Mary Ann Andrade; Glenn M. Toney; Masha Prager-Khoutorsky; Charles W. Bourque

doi:10.1016/j.celrep.2021.108866

High dietary salt amplifies osmoresponsiveness in vasopressin-releasing neurons

David I. Levi, Joshua C. Wyrosdic, Amirah Iman Hicks, Mary Ann Andrade, Glenn M. Toney, Masha Prager-Khoutorsky, Charles W. Bourque

Department of Cellular & Integrative Physiology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Levi et al. show that rats subjected to two distinct models of salt-dependent hypertension feature an increase in the osmoresponsiveness of neurosecretory neurons that release the antidiuretic and vasoconstrictor hormone vasopressin. However, this common effect is associated with different cellular and synaptic changes that characterize each of the models.

Original language	English (US)
Article number	108866
Journal	Cell Reports
Volume	34
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2021.108866
State	Published - Mar 16 2021

Keywords

angiotensin II
hypertension
mechanosensitivity
osmosensitivity
supraoptic nucleus
vasopressin

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2021.108866

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title = "High dietary salt amplifies osmoresponsiveness in vasopressin-releasing neurons",

abstract = "Levi et al. show that rats subjected to two distinct models of salt-dependent hypertension feature an increase in the osmoresponsiveness of neurosecretory neurons that release the antidiuretic and vasoconstrictor hormone vasopressin. However, this common effect is associated with different cellular and synaptic changes that characterize each of the models.",

keywords = "angiotensin II, hypertension, mechanosensitivity, osmosensitivity, supraoptic nucleus, vasopressin",

author = "Levi, {David I.} and Wyrosdic, {Joshua C.} and Hicks, {Amirah Iman} and Andrade, {Mary Ann} and Toney, {Glenn M.} and Masha Prager-Khoutorsky and Bourque, {Charles W.}",

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AU - Levi, David I.

AU - Wyrosdic, Joshua C.

AU - Hicks, Amirah Iman

AU - Andrade, Mary Ann

AU - Toney, Glenn M.

AU - Prager-Khoutorsky, Masha

AU - Bourque, Charles W.

PY - 2021/3/16

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AB - Levi et al. show that rats subjected to two distinct models of salt-dependent hypertension feature an increase in the osmoresponsiveness of neurosecretory neurons that release the antidiuretic and vasoconstrictor hormone vasopressin. However, this common effect is associated with different cellular and synaptic changes that characterize each of the models.

KW - angiotensin II

KW - hypertension

KW - mechanosensitivity

KW - osmosensitivity

KW - supraoptic nucleus

KW - vasopressin

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High dietary salt amplifies osmoresponsiveness in vasopressin-releasing neurons

Abstract

Keywords

ASJC Scopus subject areas

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