High dietary salt amplifies osmoresponsiveness in vasopressin-releasing neurons

David I. Levi, Joshua C. Wyrosdic, Amirah Iman Hicks, Mary Ann Andrade, Glenn M. Toney, Masha Prager-Khoutorsky, Charles W. Bourque

Research output: Contribution to journalArticlepeer-review

Abstract

Levi et al. show that rats subjected to two distinct models of salt-dependent hypertension feature an increase in the osmoresponsiveness of neurosecretory neurons that release the antidiuretic and vasoconstrictor hormone vasopressin. However, this common effect is associated with different cellular and synaptic changes that characterize each of the models.

Original languageEnglish (US)
Article number108866
JournalCell Reports
Volume34
Issue number11
DOIs
StatePublished - Mar 16 2021

Keywords

  • angiotensin II
  • hypertension
  • mechanosensitivity
  • osmosensitivity
  • supraoptic nucleus
  • vasopressin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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