High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes

K. G. Taylor, A. D. Wright, T. J.N. Carter, A. J. Valente, S. A. Betts, K. A. Matthews

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

High-density lipoprotein (HDL) cholesterol levels were decreased in patients with non-insulin dependent diabetes at diagnosis when matched with a control population for sex, age, obesity, alcohol consumption and cigarette smoking. There was no association between serum HDL-cholesterol concentration and the percentage of glycosylated haemoglobin A1 (HbA1). Serum HDL-cholesterol levels were lower in diabetics over the whole range of serum triglyceride levels, and particularly in hypertriglyceridaemic diabetics. Serum apolipoprotein A-I levels were not decreased in diabetics with normal serum triglyceride levels, so that the ratio of HDL cholesterol to apolipoprotein A-I was significantly decreased in diabetics (p<0.005). Decreased HDL cholesterol levels in non-insulin dependent diabetes could be relevant to the subsequent development of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)535-539
Number of pages5
JournalDiabetologia
Volume20
Issue number5
DOIs
StatePublished - May 1 1981

Keywords

  • HDL-cholesterol
  • apolipoprotein A-I
  • hypertriglyceridaemia
  • non-insulin dependent diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Taylor, K. G., Wright, A. D., Carter, T. J. N., Valente, A. J., Betts, S. A., & Matthews, K. A. (1981). High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes. Diabetologia, 20(5), 535-539. https://doi.org/10.1007/BF00252761