High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes

K. G. Taylor; A. D. Wright; T. J.N. Carter; A. J. Valente; S. A. Betts; K. A. Matthews

doi:10.1007/BF00252761

High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes

K. G. Taylor, A. D. Wright, T. J.N. Carter, A. J. Valente, S. A. Betts, K. A. Matthews

Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

High-density lipoprotein (HDL) cholesterol levels were decreased in patients with non-insulin dependent diabetes at diagnosis when matched with a control population for sex, age, obesity, alcohol consumption and cigarette smoking. There was no association between serum HDL-cholesterol concentration and the percentage of glycosylated haemoglobin A₁ (HbA₁). Serum HDL-cholesterol levels were lower in diabetics over the whole range of serum triglyceride levels, and particularly in hypertriglyceridaemic diabetics. Serum apolipoprotein A-I levels were not decreased in diabetics with normal serum triglyceride levels, so that the ratio of HDL cholesterol to apolipoprotein A-I was significantly decreased in diabetics (p<0.005). Decreased HDL cholesterol levels in non-insulin dependent diabetes could be relevant to the subsequent development of atherosclerosis.

Original language	English (US)
Pages (from-to)	535-539
Number of pages	5
Journal	Diabetologia
Volume	20
Issue number	5
DOIs	https://doi.org/10.1007/BF00252761
State	Published - May 1 1981

Keywords

HDL-cholesterol
apolipoprotein A-I
hypertriglyceridaemia
non-insulin dependent diabetes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

10.1007/BF00252761

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abstract = "High-density lipoprotein (HDL) cholesterol levels were decreased in patients with non-insulin dependent diabetes at diagnosis when matched with a control population for sex, age, obesity, alcohol consumption and cigarette smoking. There was no association between serum HDL-cholesterol concentration and the percentage of glycosylated haemoglobin A1 (HbA1). Serum HDL-cholesterol levels were lower in diabetics over the whole range of serum triglyceride levels, and particularly in hypertriglyceridaemic diabetics. Serum apolipoprotein A-I levels were not decreased in diabetics with normal serum triglyceride levels, so that the ratio of HDL cholesterol to apolipoprotein A-I was significantly decreased in diabetics (p<0.005). Decreased HDL cholesterol levels in non-insulin dependent diabetes could be relevant to the subsequent development of atherosclerosis.",

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AU - Betts, S. A.

AU - Matthews, K. A.

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