High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity

Janice P. Kim; Mark P. Goldberg; Dennis W. Choi

doi:10.1016/0014-2999(87)90349-9

High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity

Janice P. Kim, Mark P. Goldberg, Dennis W. Choi

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

(-)-Naloxone, 1 mM, partially reduced neuronal loss induced by exposure of murine cortical cell cultures to N-methyl-D-aspartate (NMDA) or quinolinate, but produced little or no attenuation of kainate or quisqualate neurotoxicity. Antagonism of NMDA neurotoxicity was (-)-naloxone concentration-dependent between 100 μM and 3 mM. (+)-Naloxone produced a slightly greater reduction of NMDA neurotoxicity, arguing against mediation by opioid receptors. Although this novel neuron-protective action of (-)-naloxone was weak, it may contribute to reported beneficial effects in CNS ischemia.

Original language	English (US)
Pages (from-to)	133-136
Number of pages	4
Journal	European Journal of Pharmacology
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(87)90349-9
State	Published - Jun 12 1987
Externally published	Yes

Keywords

(Cell culture)
N-Methyl-D-aspartate
Naloxone
Neocortex
Neurotoxicity

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(87)90349-9

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title = "High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity",

abstract = "(-)-Naloxone, 1 mM, partially reduced neuronal loss induced by exposure of murine cortical cell cultures to N-methyl-D-aspartate (NMDA) or quinolinate, but produced little or no attenuation of kainate or quisqualate neurotoxicity. Antagonism of NMDA neurotoxicity was (-)-naloxone concentration-dependent between 100 μM and 3 mM. (+)-Naloxone produced a slightly greater reduction of NMDA neurotoxicity, arguing against mediation by opioid receptors. Although this novel neuron-protective action of (-)-naloxone was weak, it may contribute to reported beneficial effects in CNS ischemia.",

keywords = "(Cell culture), N-Methyl-D-aspartate, Naloxone, Neocortex, Neurotoxicity",

author = "Kim, {Janice P.} and Goldberg, {Mark P.} and Choi, {Dennis W.}",

note = "Funding Information: manuscript assistance. This research was supported by Grants NS21628 and NS12151 from the N1H. D.W.C. is a recipient of a Hartford Fellowship from the John A. Hartford Foundation.",

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doi = "10.1016/0014-2999(87)90349-9",

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T1 - High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity

AU - Kim, Janice P.

AU - Goldberg, Mark P.

AU - Choi, Dennis W.

N1 - Funding Information: manuscript assistance. This research was supported by Grants NS21628 and NS12151 from the N1H. D.W.C. is a recipient of a Hartford Fellowship from the John A. Hartford Foundation.

PY - 1987/6/12

Y1 - 1987/6/12

N2 - (-)-Naloxone, 1 mM, partially reduced neuronal loss induced by exposure of murine cortical cell cultures to N-methyl-D-aspartate (NMDA) or quinolinate, but produced little or no attenuation of kainate or quisqualate neurotoxicity. Antagonism of NMDA neurotoxicity was (-)-naloxone concentration-dependent between 100 μM and 3 mM. (+)-Naloxone produced a slightly greater reduction of NMDA neurotoxicity, arguing against mediation by opioid receptors. Although this novel neuron-protective action of (-)-naloxone was weak, it may contribute to reported beneficial effects in CNS ischemia.

AB - (-)-Naloxone, 1 mM, partially reduced neuronal loss induced by exposure of murine cortical cell cultures to N-methyl-D-aspartate (NMDA) or quinolinate, but produced little or no attenuation of kainate or quisqualate neurotoxicity. Antagonism of NMDA neurotoxicity was (-)-naloxone concentration-dependent between 100 μM and 3 mM. (+)-Naloxone produced a slightly greater reduction of NMDA neurotoxicity, arguing against mediation by opioid receptors. Although this novel neuron-protective action of (-)-naloxone was weak, it may contribute to reported beneficial effects in CNS ischemia.

KW - (Cell culture)

KW - N-Methyl-D-aspartate

KW - Naloxone

KW - Neocortex

KW - Neurotoxicity

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High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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