To the Editor: The article by Frezza et al. (Jan. 11 issue)1 demonstrates higher blood ethanol concentrations in women than in men because of a decreased activity of gastric alcohol dehydrogenase (ADH). However, there is one important point we would like to focus on. Only younger women (<50 years of age) seem to have significantly lower gastric ADH activities in biopsy specimens from the antrum and corpus of the stomach than men; with advanced age this difference is no longer detectable (Table 1). Older women probably have even higher gastric ADH activities than men of similar age, because gastric.
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